Association of maternal chronic disease with risk of congenital heart disease in offspring

doi:10.1503/cmaj.160061

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Title:	Association of maternal chronic disease with risk of congenital heart disease in offspring
Authors:	Chou, Hsin-Hsu Chiou, Meng-Jiun Liang, Fu-Wen Chen, Lea-Hua Lu, Tsung-Hsueh Li, Chung-Yi
Contributors:	Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pediat Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth, Coll Human Ecol Natl Cheng Kung Univ, Inst Publ Hlth, Coll Med Minist Hlth & Welf, Dept Stat China Med Univ, Dept Publ Hlth, Coll Publ Hlth
Keywords:	population-based-cohort low-birth-weight cardiovascular malformations diabetes-mellitus defects prevalence pregnancy taiwan mortality infants
Date:	2016-12
Issue Date:	2018-01-18 11:40:46 (UTC+8)
Publisher:	Cma-Canadian Medical Assoc
Abstract:	Background: Information about known risk factors for congenital heart disease is scarce. In this population-based study, we aimed to investigate the relation between maternal chronic disease and congenital heart disease in offspring. Methods: The study cohort consisted of 1 387 650 live births from 2004 to 2010. We identified chronic disease in mothers and mild and severe forms of congenital heart disease in their offspring from Taiwan's National Health Insurance medical claims. We used multivariable logistic regression analysis to assess the associations of all cases and specific types of congenital heart disease with various maternal chronic diseases. Results: For mothers with the following chronic diseases, the overall prevalence of congenital heart disease in their children was significantly higher than for mothers without these diseases: diabetes mellitus type 1 (adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 1.66-3.25), diabetes mellitus type 2 (adjusted OR 2.85, 95% CI 2.60-3.12), hypertension (adjusted OR 1.87, 95% CI 1.69-2.07), congenital heart defects (adjusted OR 3.05, 95% CI 2.45-3.80), anemia (adjusted OR 1.31, 95% CI 1.25-1.38), connective tissue disorders (adjusted OR 1.39, 95% CI 1.19-1.62), epilepsy (adjusted OR 1.37, 95% CI 1.08-1.74) and mood disorders (adjusted OR 1.25, 95% CI 1.11-1.41). The same pattern held for mild forms of congenital heart disease. A higher prevalence of severe congenital heart disease was seen only among offspring of mothers with congenital heart defects or type 2 diabetes. Interpretation: The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent.
Relation:	Canadian Medical Association Journal, v.188 n.17-18, pp.E438-E446
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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