Protective effects of five allium derived organosulfur compounds against mutation and oxidation

doi:10.1016/j.foodchem.2015.11.064

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/31032

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31032

Title:	Protective effects of five allium derived organosulfur compounds against mutation and oxidation
Authors:	Chiu, Chih-Kwang Chen, Tai-Yuan Lin, Jou-Hsing Wang, Chen-Ya Wang, Bor-Sen
Contributors:	Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol Natl Taiwan Ocean Univ, Dept Food Sci Chia Nan Univ Pharm & Sci, Dept Biotechnol Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
Keywords:	Organosulfur compounds Mutation Cytotoxicity Antioxidation
Date:	2016-04
Issue Date:	2018-01-18 11:40:14 (UTC+8)
Publisher:	Elsevier Sci Ltd
Abstract:	In this study, we examined the ability of five allium-derived organosulfur compounds to protect cells against mutation and oxidation. The compounds tested were 1-propylmercaptan (PM), dimethyl disulfide (DMDS), diallyl disulfide (DADS), propyl disulfide (PDS), and 2,5-dimethylthiophene (DMT). Our results showed that when used at concentrations of 100-400 mu mol/l, the five compounds inhibited the mutagenicity of 4-nitroquinoline-N-oxide, a direct mutagen, and benzo[a]pyrene, an indirect mutagen, toward Salmonella typhimurium TA 98 and TA 100. Furthermore, at these concentrations, all five of the compounds protected HepG2 cells against tert-butyl hydroperoxide-induced oxidative cytotoxicity. The compounds likely enhanced cell viability by suppressing the formation of reactive oxygen species and the depletion of glutathione depletion in cells. DMT and PM inhibited mutation and oxidation to a greater extent than DMDS, DADS, and PDS. These results demonstrate for the first time that DMT and PM can contribute to the antimutagenic and the antioxidative property of Allium vegetables. (C) 2015 Elsevier Ltd. All rights reserved.
Relation:	Food Chemistry, v.197, pp.829-835
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles [Dept. of Biotechnology (including master's program)] Periodical Articles [Dept. of Food Science & Technology] Periodical Articles

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