Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study

doi:10.1016/j.jaci.2015.09.032

CNU IR > College of Smart Living > Dept. of Childhood Education and Nursery > Periodical Articles > Item 310902800/31028

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题名:	Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study
作者:	Yeh, Jun-Jun Wang, Yu-Chiao Hsu, Wu-Huei Kao, Chia-Hung
贡献者:	Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Chest Med & Family Med Chia Nan Univ Pharm & Sci Meiho Univ China Med Univ Hosp, Management Off Hlth Data China Med Univ Hosp, Sch Med China Med Univ Hosp, Grad Inst Clin Med Sci China Med Univ Hosp, Coll Med, Sch Med China Med Univ Hosp, Dept Nucl Med China Med Univ Hosp, PET Ctr
关键词:	Mycoplasma pneumoniae asthma antibiotic steroid cohort study surveillance
日期:	2016-04
上传时间:	2018-01-18 11:40:09 (UTC+8)
出版者:	Mosby-Elsevier
摘要:	Background: Previous studies investigating the relationship between Mycoplasma pneumoniae and incident asthma in the general population have been inconclusive. Objective: We conducted a nationwide cohort study to clarify this relationship. Methods: Using the National Health Insurance Research Database of Taiwan, we identified 1591 patients with M pneumoniae infection (International Classification of Diseases, Ninth Revision, Clinical Modification code 4830) given diagnoses between 2000 and 2008. We then frequency matched 6364 patients without M pneumoniae infection from the general population according to age, sex, and index year. Cox proportional hazards regression analysis was performed to determine the adjusted hazard ratio (aHR) of the occurrence of asthma in the M pneumoniae cohort compared with that in the non-M pneumoniae cohort. Results: Regardless of comorbidities and the use of antibiotic or steroid therapies, patients with M pneumonia infection had a higher risk of incident asthma than those without it. The aHR of asthma was 3.35 (95% CI, 2.71-4.15) for the M pneumoniae cohort, with a significantly higher risk when patients were stratified by age, sex, follow-up time, and comorbidities, including allergic rhinitis, atopic dermatitis, or allergic conjunctivitis. Patients with M pneumoniae infection had a higher risk of having early-onset (age, <12 years; aHR, 2.87) and late-onset (age, >= 12 years; aHR, 3.95) asthma. The aHR was also higher within the less than 2-year follow-up in the M pneumoniae cohort (aHR, 4.41; 95% CI, 3.40-5.74) than in the cohort without the infection. Conclusion: This study found that incident cases of early-onset and late-onset asthma are closely related to M pneumoniae infection, even in nonatopic patients.
關聯:	Journal of Allergy and Clinical Immunology, v.137 n.4, pp.1017-U566
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