Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

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Title:	Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
Authors:	Huang, Shiow-Chyn Kuo, Ping-Chung Hung, Hsin-Yi Pan, Tai-Long Chen, Fu-An Wu, Tian-Shung
Contributors:	Chia Nan Univ Pharm & Sci, Dept Pharm Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Sch Pharm, Coll Med Chang Gung Univ, Sch Tradit Chinese Med Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol Chang Gung Mem Hosp, Liver Res Ctr Tajen Univ, Dept Pharm
Keywords:	ionone Phellinus linteus fungus phellinulin hepatic fibrosis diseases
Date:	2016-05
Issue Date:	2018-01-18 11:40:00 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	Three new gamma-ionylideneacetic acid derivatives, phellinulins A-C (1-3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.
Relation:	International Journal of Molecular Sciences, v.17 n.5, 681
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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