Nonalcoholic fatty liver disease severity is associated with the ratios of total cholesterol and triglycerides to high-density lipoprotein cholesterol

doi:10.1016/j.jacl.2015.12.026

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標題:	Nonalcoholic fatty liver disease severity is associated with the ratios of total cholesterol and triglycerides to high-density lipoprotein cholesterol
作者:	Wu, Kuan-Ta Kuo, Po-Lin Su, Shih-Bin Chen, Yi-Yu Yeh, Ming-Lum Huang, Ching-I Yang, Jeng-Fu Lin, Chia-I Hsieh, Meng-Hsuan Hsieh, Ming-Yen Huang, Chung-Feng Lin, Wen-Yi Yu, Ming-Lung Dai, Chia-Yen Wang, Hsien-Yi
貢獻者:	Department of Preventive Medicine, and Health Management Center, Kaohsiung Medical University Hospital Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University Department of Occupational Medicine, Chi-Mei Medical Center Department of Medical Research, Chi-Mei Medical Center Department of Leisure, Recreation and Tourism Management, Southern Taiwan University of Science and Technology Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University Department of Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University Department of Internal Medicine, Municipal Ta-Tung Hospital, Kaohsiung Medical University Department of Occupational Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Department of Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Infectious Disease and Cancer Research, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University Institute of Biomedical Sciences, National Sun Yat-Sen University Department of Nephrology, Chi-Mei Medical Center Department of Sport Management, College of Leisure and Recreation Management, Chia-Nan University of Pharmacy and Science
關鍵字:	Hypertension Diabetes Nonalcoholic fatty liver disease (NAFLD) Hepatic steatosis Ultrasound complications
日期:	2016-04
上傳時間:	2018-01-18 11:39:54 (UTC+8)
出版者:	Elsevier Science Inc
摘要:	BACKGROUND: Limited data support the notion that lipid ratios are risk factors for nonalcoholic fatty liver disease (NAFLD). We evaluated the association between lipid ratios and NAFLD. METHODS: This was a large population, cross-sectional, retrospective study. Data on NAFLD severity, blood pressure, fasting glucose, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) levels were obtained from 44,767 examinees at single health checkup center. The enrollees were stratified into four subgroups based on their TC/HDL-C and TG/HDL-C ratios. We used multivariate analyses to evaluate the odds between lipid ratios and NAFLD. RESULTS: The prevalence rate of fatty liver in this study was 53.76%. In the baseline subgroup with the lowest TC/HDL-C and TG/HDL-C ratios, the prevalence of NAFLD, hypertension, and diabetes was lower than that of the other three subgroups. Patients with higher lipid ratios had a significantly greater risk for advanced NAFLD. CONCLUSIONS: Adults with high TC/HDL-C or TG/HDL-C ratios, or both, have a greater risk for NAFLD, especially advanced NAFLD. (C) 2016 National Lipid Association. All rights reserved.
關聯:	Journal of Clinical Lipidology, v.10 n.2, pp.420-425
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