Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31012
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23358566      Online Users : 379
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31012


    Title: A combined procedure of ultrasound-assisted and supercritical carbon dioxide for extraction and quantitation oleanolic and ursolic acids from Hedyotis corymbosa
    Authors: Yang, Yu-Chiao
    Wei, Ming-Chi
    Contributors: Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
    Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat
    Keywords: Hedyotis corymbosa
    Oleanolic acid
    Ursolic acid
    Ultrasound-assisted extraction
    Supercritical CO2 extraction
    chromatography
    Date: 2016-01
    Issue Date: 2018-01-18 11:39:48 (UTC+8)
    Publisher: Elsevier Science Bv
    Abstract: Hedyotis corymbosa is a good source of oleanolic acid (OA) and ursolic acid (UA), which have many beneficial effects on human health and are two interesting compounds that are widely utilized in medicine and functional food. To isolate OA and UA from the plant, a novel procedure employing ultrasound-assisted supercritical carbon dioxide (USC-CO2) extraction was developed, and its performance was compared with that of conventional processes. HPLC analysis of the obtained extracts revealed that the highest yields of OA (2.316 mg/g dry plant) and UA (9.284 mg/g dry plant) were achieved by USC-CO2 extraction using a dried sample with a mean particle size of 0.355 mm at a CO2 flow rate of 2.1 mL/min, temperature of 53 degrees C and pressure of 26.5 MPa. The static extraction time was 15 min and the dynamic extraction time was 80 min with 11.0% aqueous ethanol (80% (v/v) ethanol in water) as a cosolvent. The yields obtained with USC-CO2 extraction were higher than those obtained with conventional SC-CO2 extraction and heat-reflux extraction for the two discussed compounds. With the newly developed process, these results were obtained faster and at a lower temperature and pressure; additionally, less organic solvent was used. Therefore, USC-CO2 extraction, as performed under the above-mentioned conditions, is a more effective and selective method for extraction of OA and UA from H. corymbosa compared with the other two techniques. USC-CO2 extraction is efficient and environmentally friendly for using in the pharmaceutical industry. (C) 2015 Elsevier B.V. All rights reserved.
    Relation: Industrial Crops and Products, v.79, pp.7-17
    Appears in Collections:[Dept. of Applied Geoinformatics] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    31012.pdf980KbAdobe PDF0View/Open
    index.html0KbHTML1456View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback