Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31003
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18288/20515 (89%)
造访人次 : 21333022      在线人数 : 1297
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31003


    標題: Role of galectin-1 in urinary bladder urothelial carcinoma cell invasion through the JNK pathway
    作者: Shen, Kun-Hung
    Li, Chien-Feng
    Chien, Lan-Hsiang
    Huang, Cheng-Hao
    Su, Chia-Cheng
    Liao, Alex C.
    Wu, Ting-Feng
    關鍵字: Galectin-1
    invasion
    JNK
    shRNA
    urothelial bladder urinary carcinoma
    日期: 2016-10
    上傳時間: 2018-01-18 11:39:37 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Human galectin-1 is a member of the galectin family, proteins with conserved carbohydrate-recognition domains that bind galactoside. Galectin-1 is highly expressed in various tumors and participates in various oncogenic processes. However, detailed descriptions of the function of galectin-1 in urinary bladder urothelial carcinoma have not been reported. Our previous cohort investigation showed that galectin-1 is associated with tumor invasiveness and is a possible independent prognostic marker of urinary bladder urothelial carcinoma. The present study aimed to clarify the relevance of galectin-1 expression level to tumor progression and invasion. In order to decipher a mechanism for the contribution of galectin-1 to the malignant behavior of urinary bladder urothelial carcinoma, two bladder cancer cell lines (T24 and J82) were established with knockdown of galectin-1 expression by shRNA. Bladder cancer cells with LGALS1 gene silencing showed reduced cell proliferation, lower invasive capability, and lower clonogenicity. Extensive signaling pathway studies indicated that galectin-1 participated in bladder cancer cell invasion by mediating the activity of MMP9 through the Ras-Rac1-MEKK4-JNK-AP1 signaling pathway. Our functional analyses of galectin-1 in urinary bladder urothelial carcinoma provided novel insights into the critical role of galectin-1 in tumor progression and invasion. These results revealed that silencing the galectin-1-mediated MAPK signaling pathway presented a novel strategy for bladder cancer therapy.
    關聯: Cancer Science, v.107 n.10, pp.1390-1398
    显示于类别:[高齡福祉養生管理系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    31003.pdf1717KbAdobe PDF426检视/开启
    index.html0KbHTML2072检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈