Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31002
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    標題: Glutamate Decarboxylase 1 Overexpression as a Poor Prognostic Factor in Patients with Nasopharyngeal Carcinoma
    作者: Lee, Yi-Ying
    Chao, Tung-Bo
    Sheu, Ming-Jen
    Tian, Yu-Feng
    Chen, Tzu-Ju
    Lee, Sung-Wei
    He, Hong-Lin
    Chang, I-Wei
    Hsing, Chung-Hsi
    Lin, Ching-Yih
    Li, Chien-Feng
    貢獻者: Chi Mei Med Ctr, Dept Pathol
    Yuans Gen Hosp, Dept Colorectal Surg
    Meiho Univ, Dept Hlth Business Adm
    Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol
    Chi Mei Med Ctr, Div Gen Surg
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Pathol
    Chi Mei Med Ctr, Dept Radiat Oncol
    I Shou Univ, E DA Hosp, Dept Pathol
    Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol
    Chang Gung Univ, Coll Med
    Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
    關鍵字: GAD1
    nasopharyngeal carcinoma
    glutamate acid decarboxylase 1
    gamma-aminobutyric acid
    transcriptome
    Prognosis
    metastasis
    日期: 2016
    上傳時間: 2018-01-18 11:39:36 (UTC+8)
    出版者: Ivyspring Int Publ
    摘要: Background: Glutamate decarboxylase 1 (GAD1) which serves as a rate-limiting enzyme involving in the production of.-aminobutyric acid (GABA), exists in the GABAergic neurons in the central nervous system (CNS). Little is known about the relevance of GAD1 to nasopharyngeal carcinoma (NPC). Through data mining on a data set derived from a published transcriptome database, this study first identified GAD1 as a differentially upregulated gene in NPC. We aimed to evaluate GAD1 expression and its prognostic effect on patients with early and locoregionally advanced NPC. Methods: We evaluated GAD1 immunohistochemistry and performed an H-score analysis on biopsy specimens from 124 patients with nonmetastasized NPC receiving treatment. GAD1 overexpression was defined as an H score higher than the median value. The findings of such an analysis are correlated with clinicopathological behaviors and survival rates, namely disease-specific survival (DSS), distant-metastasis-free survival (DMeFS), and local recurrence-free survival (LRFS) rates. Results: GAD1 overexpression was significantly associated with an increase in the primary tumor status (p < 0.001) and American Joint Committee on Cancer (AJCC) stages III-IV (p = 0.002) and was a univariate predictor of adverse outcomes of DSS (p = 0.002), DMeFS (p < 0.0001), and LRFS (p = 0.001). In the multivariate comparison, in addition to advanced AJCC stages III-IV, GAD1 overexpression remained an independent prognosticator of short DSS (p = 0.004, hazard ratio = 2.234), DMeFS (p < 0.001, hazard ratio = 4.218), and LRFS (p = 0.013, hazard ratio = 2.441) rates. Conclusions: Our data reveal that GAD1 overexpression was correlated with advanced disease status and may thus be a critical prognostic indicator of poor outcomes in NPC and a potential therapeutic target to facilitate the development of effective treatment modalities.
    關聯: Journal of Cancer, v.7 n.12, pp.1716-1723
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