Determination of Nicotinic Acid and Metabolites in Urine, Cosmetics, and Pharmaceuticals by High-Performance Liquid Chromatography with Novel Electrochemical Detection

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/30993

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/30993

Title:	Determination of Nicotinic Acid and Metabolites in Urine, Cosmetics, and Pharmaceuticals by High-Performance Liquid Chromatography with Novel Electrochemical Detection
Authors:	Wang, Lai-Hao
Contributors:	Chia Nan Univ Pharm & Sci, Dept Med Chem
Keywords:	Electrochemical detector high-performance liquid chromatography nicotinic acid
Date:	2016
Issue Date:	2018-01-18 11:39:26 (UTC+8)
Publisher:	Taylor & Francis Inc
Abstract:	Silver and gold electrodes were used with high-performance liquid chromatography and an electrochemical detector to determine nicotinic acid and its metabolites (1-methylnicotinamide chloride, nicotinic acid hydroxamate, nicotinamide, nicotinic acid, and methyl nicotinate). Nicotinic acid derivatives were more efficiently oxidized on a gold electrode than on a silver electrode. In direct current mode, with the current at a constant potential and with suitable experimental parameters, linear dynamic range for these derivatives was from 0.4 to 8.0 mg L-1. The limits of quantification were less than 1.0 ng. The developed method was used to determine nicotinic acid and its derivatives in human urine, cosmetics, and pharmaceuticals. The results for high-performance liquid chromatography with electrochemical and ultraviolet detection were comparable.
Relation:	Analytical Letters, v.49 n.10, pp.1467-1479
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1366	View/Open