Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30993
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    Title: Determination of Nicotinic Acid and Metabolites in Urine, Cosmetics, and Pharmaceuticals by High-Performance Liquid Chromatography with Novel Electrochemical Detection
    Authors: Wang, Lai-Hao
    Contributors: Chia Nan Univ Pharm & Sci, Dept Med Chem
    Keywords: Electrochemical detector
    high-performance liquid chromatography
    nicotinic acid
    Date: 2016
    Issue Date: 2018-01-18 11:39:26 (UTC+8)
    Publisher: Taylor & Francis Inc
    Abstract: Silver and gold electrodes were used with high-performance liquid chromatography and an electrochemical detector to determine nicotinic acid and its metabolites (1-methylnicotinamide chloride, nicotinic acid hydroxamate, nicotinamide, nicotinic acid, and methyl nicotinate). Nicotinic acid derivatives were more efficiently oxidized on a gold electrode than on a silver electrode. In direct current mode, with the current at a constant potential and with suitable experimental parameters, linear dynamic range for these derivatives was from 0.4 to 8.0 mg L-1. The limits of quantification were less than 1.0 ng. The developed method was used to determine nicotinic acid and its derivatives in human urine, cosmetics, and pharmaceuticals. The results for high-performance liquid chromatography with electrochemical and ultraviolet detection were comparable.
    Relation: Analytical Letters, v.49 n.10, pp.1467-1479
    Appears in Collections:[Dept. of Medicinal Chemistry] Periodical Articles

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