Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30993
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17778/20119 (88%)
Visitors : 12244757      Online Users : 292
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30993


    Title: Determination of Nicotinic Acid and Metabolites in Urine, Cosmetics, and Pharmaceuticals by High-Performance Liquid Chromatography with Novel Electrochemical Detection
    Authors: Wang, Lai-Hao
    Contributors: Chia Nan Univ Pharm & Sci, Dept Med Chem
    Keywords: Electrochemical detector
    high-performance liquid chromatography
    nicotinic acid
    Date: 2016
    Issue Date: 2018-01-18 11:39:26 (UTC+8)
    Publisher: Taylor & Francis Inc
    Abstract: Silver and gold electrodes were used with high-performance liquid chromatography and an electrochemical detector to determine nicotinic acid and its metabolites (1-methylnicotinamide chloride, nicotinic acid hydroxamate, nicotinamide, nicotinic acid, and methyl nicotinate). Nicotinic acid derivatives were more efficiently oxidized on a gold electrode than on a silver electrode. In direct current mode, with the current at a constant potential and with suitable experimental parameters, linear dynamic range for these derivatives was from 0.4 to 8.0 mg L-1. The limits of quantification were less than 1.0 ng. The developed method was used to determine nicotinic acid and its derivatives in human urine, cosmetics, and pharmaceuticals. The results for high-performance liquid chromatography with electrochemical and ultraviolet detection were comparable.
    Relation: Analytical Letters, v.49 n.10, pp.1467-1479
    Appears in Collections:[Dept. of Medicinal Chemistry] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML497View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback