Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30987
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    標題: Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice
    作者: Chou, Yen-Jung
    Kan, Wei-Chih
    Chang, Chieh-Min
    Peng, Yi-Jen
    Wang, Hsien-Yi
    Yu, Wen-Chun
    Cheng, Yu-Hsuan
    Jhang, Yu-Rou
    Liu, Hsia-Wei
    Chuu, Jiunn-Jye
    貢獻者: En Chu Kong Hosp, Dept Tradit Chinese Med
    Chi Mei Med Ctr, Dept Med, Div Nephrol
    Chung Hwa Univ Med Technol, Dept Biol Sci & Technol
    Triserv Gen Hosp, Natl Def Med Ctr, Dept Pathol
    Chia Nan Univ Pharm & Sci, Dept Sports Management, Coll Leisure & Recreat Management
    Natl Def Med Ctr, Grad Inst Life Sci
    Southern Taiwan Univ Sci & Technol, Inst Biotechnol
    Fu Jen Catholic Univ, Dept Life Sci
    Wei Gong Mem Hosp, Pharm
    關鍵字: diabetic nephropathy
    Inonotus obliquus
    polysaccharides
    renal fibrosis
    advanced glycation end products (AGE)
    NF-B
    TGF-
    medicinal mushroom
    日期: 2016-09
    上傳時間: 2018-01-18 11:39:17 (UTC+8)
    出版者: Mdpi Ag
    摘要: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in diabetes mellitus. Oxidative stress, insulin resistance and pro-inflammatory cytokines have been shown to play an important role in pathogeneses of renal damage on type 2 diabetes mellitus (DM). Inonotus obliquus (IO) is a white rot fungus that belongs to the family Hymenochaetaceae; it has been used as an edible mushroom and exhibits many biological activities including anti-tumor, anti-oxidant, anti-inflammatory and anti-hyperglycemic properties. Especially the water-soluble Inonotus obliquus polysaccharides (IOPs) have been previously reported to significantly inhibit LPS-induced inflammatory cytokines in mice and protect from streptozotocin (STZ)-induced diabetic rats. In order to identify the nephroprotective effects of low molecular weight of IOP fraction (LIOP), from the fruiting bodies of Inonotus obliquus, high-fat diet (HFD) plus STZ-induced type 2-like diabetic nephropathy C57BL/6 mice were investigated in this study. Our data showed that eight weeks of administration of 10-100 kDa, LIOP (300 mg/kg) had progressively increased their sensitivity to glucose (less insulin tolerance), reduced triglyceride levels, elevated the HDL/LDL ratio and decreased urinary albumin/creatinine ratio(ACR) compared to the control group. By pathological and immunohistochemical examinations, it was indicated that LIOP can restore the integrity of the glomerular capsules and increase the numbers of glomerular mesangial cells, associated with decreased expression of TGF- on renal cortex in mice. Consistently, three days of LIOP (100 g/mL) incubation also provided protection against STZ + AGEs-induced glucotoxicity in renal tubular cells (LLC-PK1), while the levels of NF-B and TGF- expression significantly decreased in a dose-dependent manner. Our findings demonstrate that LIOP treatment could ameliorate glucolipotoxicity-induced renal fibrosis, possibly partly via the inhibition of NF-B/TGF-1 signaling pathway in diabetic nephropathy mice.
    關聯: International Journal of Molecular Sciences, v.17 n.9, 1535
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