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https://ir.cnu.edu.tw/handle/310902800/30972
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| 標題: | Efficacy of Femarelle for the treatment of climacteric syndrome in postmenopausal women: An open label trial |
| 作者: | Chen, Fang-Ping
Chang, Chee Jen
Chao, An-Shine
Huang, Hong-Yuan
Huang, Jian-Pei
Wu, Meng-Hsing
Tsai, Ching-Chou
Kung, Fu-Tsai
Chang, Ching-Wen
Tsai, Yung-Chieh |
| 貢獻者: | Chang Gung Mem Hosp, Dept Obstet & Gynecol
Chang Gung Mem Hosp, Dept Obstet & Gynecol
Chang Gung Mem Hosp, Dept Obstet & Gynecol
Chang Gung Univ
Chang Gung Univ, Clin Informat & Med Stat Res Ctr
Mackay Mem Hosp, Dept Obstet & Gynecol
Coll Med & Hosp, Dept Obstet & Gynecol
Natl Cheng Kung Univ
Taipei Med Univ Hosp, Dept Obstet & Gynecol
Chi Mei Med Ctr
Chia Nan Univ Pharm & Sci, Dept Sport Management |
| 關鍵字: | climacteric syndrome
Femarelle
hot flushes
postmenopausal women
rats |
| 日期: | 2016-06 |
| 上傳時間: | 2018-01-18 11:38:59 (UTC+8) |
| 出版者: | Elsevier Taiwan |
| 摘要: | Objective: To assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women. Materials and methods: A multi-center, open-label trial of 260 postmenopausal women, age >= 45 years with vasomotor symptoms. Women were enrolled after obtaining a detailed medical history and a thorough physical examination. They then received Femarelle (640 mg/d) twice daily for 8 weeks. The primary outcome was the changes in the frequency and severity of hot flushes from baseline to 4 weeks (1 month) and 8 weeks (2 months). Changes of general climacteric syndrome were assessed using a modified climacteric scale designed by Greene. Results: The frequency and severity of hot flushes were significantly improved with Femarelle use (p < 0.001). After 8 weeks of treatment, the percentage of women with various climacteric syndromes was reduced (from 100% to 20.9% for hot flushes, from 97.7% to 87.9% for psychological symptoms, from 93.8% to 78.8% for somatic symptoms, and from 87.8% to 74.9% for sexual symptoms). General climacteric syndrome scores also significantly decreased, from 20.8 +/- 0.7 at the time of enrollment to 12.9 +/- 0.7 after 8 weeks of Femarelle treatment (p < 0.0001). Participants experienced improvement of various climacteric symptoms and signs after 8 weeks of treatment (75.1% for hot flushes, 68.7% for psychological symptoms, 70.6% for somatic symptoms, and 69.0% for sexual problems respectively). After 4 weeks and 8 weeks of treatment with Femarelle, patients showed statistically significant improvement in climacteric symptoms (p < 0.0001). Three women (1.2%) withdrew from the study after 4 weeks of treatment due to adverse effects. Conclusion: Femarelle significantly improved climacteric symptoms in Taiwanese postmenopausal women. However, further evaluation is needed regarding the safety of long-term consumption. Copyright (C) 2016, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. |
| 關聯: | Taiwanese Journal of Obstetrics & Gynecology, v.55 n.3, pp.336-340 |
| 顯示於類別: | [運動管理系] 期刊論文
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