Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

doi:10.2217/fon-2016-0071

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標題:	Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy
作者:	Chao, Tung-Bo Li, Chien-Feng Lin, Ching-Yih Tian, Yu-Feng Chang, I-Wei Sheu, Ming-Jen Lee, Ying-En Chan, Ti-Chun He, Hong-Lin
貢獻者:	Yuans Gen Hosp, Dept Colorectal Surg Meiho Univ, Dept Hlth Business Adm Chi Mei Med Ctr, Dept Pathol Natl Hlth Res Inst, Natl Inst Canc Res Southern Taiwan Univ Sci & Technol, Dept Biotechnol Kaohsiung Med Univ, Inst Clin Med Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Chi Mei Med Ctr, Dept Surg, Div Gen Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr I Shou Univ, E DA Hosp, Dept Pathol Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol
關鍵字:	chemoradiotherapy DSG3 rectal cancer radiotherapy
日期:	2016-06
上傳時間:	2018-01-18 11:38:53 (UTC+8)
出版者:	Future Medicine Ltd
摘要:	Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
關聯:	Future Oncology, v.12 n.12, pp.1457-1467
顯示於類別:	[保健營養系(所) ] 期刊論文

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