Pegylated Liposomal Doxorubicin as Adjuvant Therapy for Stage I-III Operable Breast Cancer

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/30959

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/30959

標題:	Pegylated Liposomal Doxorubicin as Adjuvant Therapy for Stage I-III Operable Breast Cancer
作者:	Lu, Yin-Che Ou-Yang, Fu Hsieh, Chia-Ming Chang, King-Jen Chen, Dar-Ren Tu, Chi-Wen Wang, Hwei-Chung Hou, Ming-Feng
貢獻者:	Ditmanson Med Fdn Chiayi Christian Hosp, Dept 1Hematol Oncol Ditmanson Med Fdn Chiayi Christian Hosp, Dept Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Kaohsiung Med Univ Hosp, Dept Surg Taiwan Adventist Hosp, Breast Ctr Natl Taiwan Univ Hosp, Dept Surg Cheng Ching Gen Hosp, Dept Surg Changhua Christian Hosp, Dept Surg China Med Univ Hosp, Dept Surg Kaohsiung Municipal Hsiaokang Hosp
關鍵字:	Breast cancer adjuvant chemotherapy pegylated liposomal doxorubicin older
日期:	2016-03
上傳時間:	2018-01-18 11:38:44 (UTC+8)
出版者:	Int Inst Anticancer Research
摘要:	Background: Conventional anthracyclines play an essential role for the treatment of breast cancer and have potent cytotoxic activity, but are associated with severe toxicity. In metastatic breast cancer, pegylated liposomal doxorubicin (PLD) is a formulation with efficacy similar to conventional doxorubicin but with reduced toxicity. This multicenter study evaluated the efficacy and safety of PLD-based adjuvant chemotherapy for women with stage I-III operable breast cancer. Patients and Methods: One hundred and eighty women with stage I-III breast cancer who received PLD-based adjuvant chemotherapy at six different Institutions in Taiwan from February 2002 to March 2008 were included and followed-up until April 2015. Treatment efficacy was determined by disease-free survival (DFS) rate and safety was evaluated by adverse events. Results: The 5- and 10-year DFS rates were 76.3 and 72.6%, respectively. Univariate analysis revealed that tumor size >5 cm (p=0.045; hazard ratio=3.31) and stage III (hazard ratio=3.54; p=0.019) were each associated with shorter DFS. Only stage III (hazard ratio=5.60; p=0.018) retained statistical significance with regard to DFS in the multivariate analysis. Grade 3/4 hematological toxicity was neutropenia (n=13; 7.2%). The women receiving PLD had low-grade 3 or 4 nausea/vomiting, mucositis, and alopecia. Grade 3 hand-foot syndrome occurred in three patients (1.7%). Conclusion: PLD could be considered an effective and safe alternative to conventional anthracyclines in the treatment of stage I-III operable breast cancer.
關聯:	In Vivo, v.30 n.2, pp.158-162
顯示於類別:	[保健營養系(所) ] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
30959.pdf		77Kb	Adobe PDF	545	檢視/開啟
index.html		0Kb	HTML	1989	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....