Thermo- and pH-Induced Self-Assembly of P(AA-b-NIPAAm-b-AA) Triblock Copolymers Synthesized via RAFT Polymerization

doi:10.1002/pola.27950

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/30958

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標題:	Thermo- and pH-Induced Self-Assembly of P(AA-b-NIPAAm-b-AA) Triblock Copolymers Synthesized via RAFT Polymerization
作者:	Kuo, Chih-Yu Don, Trong-Ming Hsu, Shih-Chi Lee, Chia-Fen Chiu, Wen-Yen Huang, Chih-Yuan
貢獻者:	Natl Taiwan Univ, Inst Polymer Sci & Engn Tamkang Univ, Dept Chem & Mat Engn Natl Taiwan Univ, Dept Mat Sci & Engn Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Nan Univ Pharm & Sci, Inst Cosmet Sci Natl Taiwan Univ, Dept Chem Engn
關鍵字:	block copolymer core-shell particles nanogels reversible addition fragmentation chain transfer (RAFT) RAFT polymerization self-assembly stimuli-sensitive polymers nanocarriers
日期:	2016-04
上傳時間:	2018-01-18 11:38:43 (UTC+8)
出版者:	Wiley
摘要:	A series of environmentally sensitive ABA triblock copolymers with different block lengths were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization from acrylic acid (AA) and N-isopropylacrylamide (NIPAAm). The GPC and H-1 NMR analyses demonstrated the narrow molecular weight distribution and precise chemical structure of the prepared P(AA-b-NIPAAm-b-AA) triblock copolymers owing to the controlled/living characteristics of RAFT polymerization. The lower critical solution temperature (LCST) of the triblock copolymers could be tailored by adjusting the length of PAA block and controlled by the pH value. Under heating, the triblock copolymers underwent self-assemble in dilute aqueous solution and formed nanoparticles revealed via TEM images. Physically crosslinked nanogels induced by inter-/intra-hydrogen bonding or core-shell micelle particles thus could be obtained by changing environmental conditions. With a well-defined structure and stimuli-responsive properties, the P(AA-b-NIPAAm-b-AA) copolymer is expected to be employed as a nanocarrier for biomedical applications in controlled-drug delivery and targeting therapy. (C)2015 Wiley Periodicals, Inc.
關聯:	Journal of Polymer Science Part A-Polymer Chemistry, v.54 n.8, pp.1109-1118
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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