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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30942

    標題: Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia
    作者: Chen, Min-Chan
    Chen, Yi-Ling
    Wang, Tzu-Wen
    Hsu, Hui-Ping
    Lai, Ming-Derg
    貢獻者: Chi Mei Med Ctr, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Sports Management, Coll Leisure & Recreat Management
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management, Coll Leisure & Recreat Management
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Surg, Coll Med
    Natl Cheng Kung Univ, Dept Biochem & Mol Biol
    Natl Cheng Kung Univ, Inst Basic Med Sci
    Natl Cheng Kung Univ, Coll Med, Ctr Infect Dis & Signaling Res
    關鍵字: ampullary adenocarcinoma
    bile acids
    Kaplan-Meier plotter
    日期: 2016-10
    上傳時間: 2018-01-18 11:38:23 (UTC+8)
    出版者: Spandidos Publ Ltd
    摘要: Bile acids are potential carcinogens in gastrointestinal cancer, and interact with nuclear and membrane receptors to initiate downstream signaling. The effect of TGR5 [also known as G protein-coupled bile acid receptor 1 (GPBAR1)] on cancer progression is dependent on the tissue where it is activated. In this report, the function of TGR5 expression in cancer was studied using a bioinformatic approach. TGR5 expression in ampullary adenocarcinoma and normal duodenum was compared by western blotting, reverse transcription polymerase chain reaction, and immunohistochemistry (IHC). High GPBAR1 gene expression was found to be an indicator of worse prognosis in gastric and breast cancer patients, and an indication of better prognosis in ovarian cancer patients. The level of GPBAR1 gene expression was higher in bile-acid exposed cancer than in other types of cancer, and was increased in well-differentiated ampullary adenocarcinoma. Negative, weak or mild expression of TGR5 was correlated with younger age, higher plasma level of total/direct bilirubin, higher plasma concentration of CA-125, advanced tumor stage and advanced AJCC TNM stage. The disease-specific survival rate was highest in ampullary adenocarcinoma patients with high TGR5 expression and high total bilirubin level. In summary, TGR5 functions as a tumor-suppressor in patients with ampullary adenocarcinoma and preoperative hyperbilirubinemia. Further study of the suppressive mechanism may provide a new therapeutic option for patients with ampullary adenocarcinoma.
    關聯: Oncology Reports, v.36 n.4, pp.1997-2008
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