Prognostic Factors in Patients With Pulmonary Hypertension-A Nationwide Cohort Study

doi:10.1161/JAHA.116.003579

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/30941

Title:	Prognostic Factors in Patients With Pulmonary Hypertension-A Nationwide Cohort Study
Authors:	Chang, Wei-Ting Weng, Shih-Feng Hsu, Chih-Hsin Shih, Jhih-Yuan Wang, Jhi-Joung Wu, Chun-Ying Chen, Zhih-Cherng
Contributors:	Chi Mei Med Ctr, Dept Cardiol Chi Mei Med Ctr, Dept Med Res Southern Taiwan Univ Sci & Technol, Dept Biotechnol Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat Cheng Kung Univ Hosp, Dept Internal Med Taichung Vet Gen Hosp, Div Gastroenterol Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	age mortality pulmonary hypertension sex disease
Date:	2016-09
Issue Date:	2018-01-18 11:38:22 (UTC+8)
Publisher:	Wiley-Blackwell
Abstract:	Background-Pulmonary hypertension (PH) is a rare but fatal condition. Large-scale studies to examine the prognostic factors are lacking. In the present study, we aimed to investigate the factors associated with overall mortality in PH patients. Methods and Results-Based on Taiwan's National Health Insurance Database, we identified 1092 newly identified PH patients between 1999 and 2011. These patients were matched with 8736 healthy subjects based on propensity score calculated with age, sex, and chronic cardiovascular risk factors. Overall mortality, death incidence rate ratio, and hazard ratio were calculated. Patients with PH had a higher mortality than controls (56.45 versus 18.51 per 1000 person-years, P<0.0001), with hazard ratio at 3.3 (95% CI: 2.92-3.73, P<0.001). The long-term survival rates of the PH patients at 1, 5, and 10 years were 87.9%, 72.5%, and 62.6%, respectively, which were significantly lower than controls with 98.4%, 90.8%, and 83.6% at 1, 5, and 10 years, respectively. Among patients with PH, the mortality rate was higher in the older and male patients. However, after stratifying by age and sex, the younger (<50 years) and female patients had a higher risk. Regarding different etiologies of PH, chronic obstructive pulmonary disease and pulmonary embolism led to most cases of mortality (adjusted hazard ratio: 3.2, 95% CI: 2.76-3.71 and 4.64, 95% CI: 2.74-7.87, P<0.05). Conclusions-PH has high mortality, especially in females, and patients with younger age and with chronic diseases. Chronic obstructive pulmonary disease and pulmonary embolism contributed to an increased risk of mortality in PH patients.
Relation:	Journal of the American Heart Association, v.5 n.9, e003579
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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