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https://ir.cnu.edu.tw/handle/310902800/30935
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| 標題: | Secondhand Smoke Exposure Enhances Cardiac Fibrosis Effects on the Aging Rat Hearts |
| 作者: | Wu, Jia-Ping
Chang-Lee, Shu Nu
Day, Cecilia Hsuan
Ho, Tsung-Jung
Viswanadha, Vijaya Padma
Chung, Li-Chin
Hwang, Jin-Ming
Jong, Gwo-Ping
Kuo, Wei-Wen
Huang, Chih-Yang |
| 貢獻者: | China Med Univ, Grad Inst Basic Med Sci
Asia Univ, Dept Healthcare Adm
MeiHo Univ, Dept Nursing
China Med Univ, Grad Inst Chinese Med
China Med Univ, Chinese Med Dept, Beigang Hosp
Bharathiar Univ, Dept Biotechnol, Coimbatore
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Chung Shan Med Univ, Sch Appl Chem
Armed Force Taichung Gen Hosp, Div Cardiol
China Med Univ, Dept Biol Sci & Technol
Asia Univ, Dept Hlth & Nutr Biotechnol |
| 關鍵字: | Aging
Basic fibroblast growth factors
Connective tissue growth factor
Extracellular matrix
Secondhand smoke exposure
infarction |
| 日期: | 2016-09 |
| 上傳時間: | 2018-01-18 11:38:15 (UTC+8) |
| 出版者: | Taiwan Soc Cardiology |
| 摘要: | Background: Examining aging rats exposed to secondhand smoke (SHS) engenders changes in left ventricular remodeling due to age- or disease-dependent alterations. Methods: Rats were placed in whole-body exposure chambers and exposed to 10 cigarettes. Filtered air was introduced into the chamber at a low rate. Rats were exposed to SHS for 30 min, twice a day, 5 days per week for 1 month. After 4 weeks SHS exposure, rats were sacrificed for morphological study with trichome staining and left ventricular remodeling related protein analysis using western blot. Results: Characteristic fibrotic morphology in the left ventricle increased significantly with aging and exposure to SHS. Exposure to SHS elevated TGF1 beta 1/p-Smad2/3/CTGF and MMP2/MMP9 protein expression levels (p < 0.05). No significant differences in FGF-2 and UPA protein expression were noted as a result of SHS exposure. However, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 protein expression were suppressed by SHS exposure. We also observed increased TGF beta 1/p-Smad2/3/CTGF (p < 0.01), FGF-2/UPA (p < 0.05) and decreased TIMPs protein expression levels. Corresponding MMP2 and MMP9 upregulation occurred with aging and exposure to SHS. TGF beta 1/p-Smad2/3/CTGF and FGF-2/UPA protein expression from SHS exposure were higher than that from aging. In contrast, MMP2 and MMP9 were increased in aging rats compared with SHS exposed rats (p < 0.05); however, TIMP-1 (p < 0.01), TIMP-2 (p < 0.01) and TIMP-3 (p < 0.05) were decreased. TIMP-4 protein expression levels were decreased compared with SHS exposed rats (p < 0.01). Conclusions: Aging and SHS exposure in rats will produce elevated fibrosis. Exposure to SHS will accelerate aging and left ventricular fibrosis. |
| 關聯: | Acta Cardiologica Sinica, v.32 n.5, pp.594-603 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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