Clinical characteristics and prevalence of complications of chronic kidney disease in children: the Taiwan Pediatric Renal Collaborative study

doi:10.1007/s00467-016-3325-5

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Title:	Clinical characteristics and prevalence of complications of chronic kidney disease in children: the Taiwan Pediatric Renal Collaborative study
Authors:	Chou, Hsin-Hsu Lin, Ching-Yuang Chiou, Yee-Hsuan Tain, You-Lin Wang, Yi-Fan Wang, Hsin-Hui Chiou, Yuan-Yow
Contributors:	Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pediat, Div Pediat Nephrol Chia Nan Univ Pharm & Sci, Coll Human Ecol, Dept Appl Life Sci & Hlth China Med Univ, Med Coll & Hosp, Clin Immunol Ctr Kaohsiung Vet Gen Hosp, Dept Pediat Kaohsiung Chang Gung Mem Hosp, Coll Med, Div Pediat Nephrol Chang Gung Univ Kaohsiung Med Univ Hosp, Div Pediat Nephrol Taipei Vet Gen Hosp, Dept Pediat, Div Pediat Immunol & Nephrol Natl Yang Ming Univ, Dept Pediat, Fac Med, Sch Med Natl Yang Ming Univ, Inst Emergency & Crit Care Med Natl Cheng Kung Univ Hosp, Dept Pediat, Div Pediat Nephrol Natl Cheng Kung Univ, Coll Med, Dept Pediat
Keywords:	Children Chronic kidney diseases Clinical characteristics Etiology Prevalence of complications
Date:	2016-07
Issue Date:	2018-01-18 11:38:07 (UTC+8)
Publisher:	Springer
Abstract:	Little information is available regarding the clinical characteristics and prevalence of complications in children with chronic kidney disease (CKD), especially in early disease stages. The objective of this study was to determine the clinical characteristics and prevalence of complications in children with predialytic CKD. This multicenter, cross-sectional study enrolled children at all stages of predialytic CKD. Children who were between the ages of 1 year and 18 years and who fulfilled the clinical criteria of CKD were included in the study. Baseline demographic data, previous history, clinical characteristics, and laboratory data were collected. A total of 757 children were included in the study. The median age at the time of enrollment was 10.6 years; 397 patients (52.4 %) were males. A total of 39.0 % of the patients were in CKD stage 1, 37.6 % were in stage 2, 14.8 % were in stage 3, 3.0 % were in stage 4, and 5.5 % were in stage 5. Nonglomerular renal diseases were the primary cause of CKD, comprising 51.9 % of the patients with CKD. The age at disease onset, gender, CKD stage distribution, and proportion of co-morbidities varied between the glomerular and nonglomerular CKD cases. Anemia, hyperlipidemia, hypocalcemia, and hyperphosphatemia were more prevalent in patients with glomerular CKD. The overall prevalence of complications was as follows: uncontrolled blood pressure, 44.1 %; anemia, 34.2 %; hyperlipidemia, 44.9 %; short stature, 10.3 %; and failure to thrive, 8.2 %. Uncontrolled blood pressure (BP), anemia, and hyperlipidemia were common, even in the early CKD stages. The prevalence of CKD complications generally increased with the worsening stage of CKD. This study reveals differences in CKD etiology and prevalence of specific complications according to the stage of CKD. Early recognition and awareness of complications are mandatory for clinicians during the follow-up visits of children with CKD.
Relation:	Pediatric Nephrology, v.31 n.7, pp.1113-1120
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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