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標題: | Monomicrobial Aeromonas and Vibrio bacteremia in cirrhotic adults in southern Taiwan: Similarities and differences |
作者: | Syue, Ling-Shan Chen, Po-Lin Wu, Chi-Jung Lee, Nan-Yao Lee, Ching-Chi Li, Chia-Wen Li, Ming-Chi Tang, Hung-Jen Hsueh, Po-Ren Ko, Wen-Chien |
貢獻者: | Natl Cheng Kung Univ, Coll Med & Hosp, Dept Internal Med Natl Cheng Kung Univ, Grad Inst Clin Med, Coll Med Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol Natl Cheng Kung Univ Hosp, Ctr Infect Control Chi Mei Med Ctr, Dept Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Lab Med Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Coll Med |
關鍵字: | Aeromonas bacteremia liver cirrhosis Vibrio liver |
日期: | 2016-08 |
上傳時間: | 2018-01-18 11:37:47 (UTC+8) |
出版者: | Elsevier Taiwan |
摘要: | Background/Purpose: Aeromonas and Vibrio are important water-borne pathogens causing substantial morbidity and mortality in cirrhotic patients in Taiwan, but the differences in clinical manifestations of Aeromonas and Vibrio bacteremia have not been reported in detail. Methods: From January 2003 to September 2013, cirrhotic patients with monomicrobial Aeromonas or Vibrio bacteremia at a medical center in Taiwan were included in this study. Results: The study population consisted of 77 cirrhotic patients with Aeromonas bacteremia and 48 patients with Vibrio bacteremia. Both pathogens clustered during the summer season; Vibrio bacteremia was more correlated with higher temperatures (Vibrio: r(2) = 0.95, p < 0.0001; Aeromonas: r(2) = 0.74, p = 0.006) and was associated with ingestion of undercooked seafood (p = 0.03) or cutaneous exposure (p < 0.001). Vibrio bacteremia mainly occurred in mildly or moderately decompensated cirrhosis (ChildePugh class A and B: 45.8% vs. 20.8%, p = 0.003), and caused more soft-tissue infections (31.3% vs. 5.2%; p < 0.001) and renal dysfunction (1.6 +/- 1.2 mg/dL vs. 1.3 +/- 0.8 mg/dL, p = 0.006). Sepsis-related mortality was similar in the cases of Vibrio and Aeromonas bacteremia (14.6% vs. 14.3%, p = 0.96), but those with Vibrio bacteremia underwent a fulminant course, as evidenced by a shorter time from bacteremia onset to death (3.1 days vs. 8.2 days, p = 0.04). Conclusion: In cirrhotic patients, bacteremia caused by Aeromonas and Vibrio species clustered in summer months and caused similar mortality, but Vibrio bacteremia led to a more severe and fulminant sepsis. Copyright (C) 2014, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
關聯: | Journal of Microbiology Immunology and Infection, v.49 n.4, pp.509-515 |
顯示於類別: | [保健營養系(所) ] 期刊論文
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