Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor

doi:10.18632/oncotarget.7038

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/30902

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/30902

Title:	Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor
Authors:	Tu, Dom-Gene Chang, Wen-Wei Lin, Song-Tao Kuo, Chun-Yu Tsao, Yu-Tzu Lee, Che-Hsin
Contributors:	Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Nucl Med Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol Chang Jung Christian Univ, Coll Hlth Sci Chung Shan Med Univ, Coll Med Sci & Technol, Dept Biomed Sci Chung Shan Med Univ Hosp, Dept Med Res China Med Univ, Sch Med, Dept Microbiol China Med Univ, Sch Med, Grad Inst Basic Med Sci Taoyuan Gen Hosp, Dept Med Natl Sun Yat Sen Univ, Dept Biol Sci
Keywords:	Salmonella tumor-targeting angiogenesis hypoxia-inducible factor-1 alpha vascular endothelial growth factor efficacy
Date:	2016-06
Issue Date:	2018-01-18 11:37:35 (UTC+8)
Publisher:	Impact Journals Llc
Abstract:	Salmonella is a Gram-negative, facultative anaerobe that is a common cause of host intestinal infections. Salmonella grows under aerobic and anaerobic conditions, and it has been proven capable of inhibiting tumor growth. However, the molecular mechanism by which Salmonella inhibits tumor growth is still unclear. Angiogenesis plays an important role in the development and progression of tumors. We investigated the antitumor effect of Salmonella in a syngeneic murine tumor model. Hypoxia-inducible factor-1 (HIF-1) a plays a significant role in tumor angiogenesis. We examined the molecular mechanism by which Salmonella regulated vascular endothelial growth factor (VEGF), which is an important angiogenic factor. The expression of VEGF in tumor cells was decreased by treatment with Salmonella. The conditioned medium from Salmonella-treated cells inhibited the proliferation of endothelial cells. Salmonella inhibited the expression of HIF-1 alpha as well as downregulated its upstream signal mediator protein kinase B (AKT). Salmonella significantly inhibited tumor growth in vivo, and immunohistochemical studies of the tumors revealed decreased intratumoral microvessel density. These results suggest that Salmonella therapy, which exerts anti-angiogenic activities, represents a promising strategy for the treatment of tumors.
Relation:	Oncotarget, v.7 n.25, pp.37513-37523
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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