紅藜及其活性成分對原發性高血壓大鼠血壓之影響

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Title:	紅藜及其活性成分對原發性高血壓大鼠血壓之影響 Effects of Chenopodium formosanum and Its Active Compounds on Blood Pressure In Spontaneously Hypertensive Rats
Authors:	楊景雯
Contributors:	保健營養系陳師瑩杜平惪
Keywords:	紅藜高血壓血管收縮素轉化酶 Djulis Hypertensive Angiotensin converting enzyme
Date:	2017
Issue Date:	2018-01-11 11:42:35 (UTC+8)
Abstract:	高血壓是威脅全世界健康的主要疾病。本研究旨在探討紅藜 (WECF) 及其生物活性成分芸香苷 (Rutin) 和甜菜苷 (Betanin) 對原發性高血壓大鼠 (SHR) 的降血壓作用。以十週齡SHR和正常血壓 (WKY) 大鼠。SHR大鼠分別給予Rutin (50 mg/kg bw，R組)、Betanin (50 mg/kg bw，B組)、紅藜低劑量 (10 mg/kg bw，L組) 、紅藜中劑量 (50 mg/kg bw，M組) 、紅藜高劑量 (100 mg/kg bw，H組) 或卡托普利 (50mg / kg bw，CA組) ，實驗為期21天。使用大鼠非侵入性血壓機尾套法測量收縮壓 (SBP) 和舒張壓 (DBP) 。測定大鼠血漿中的血管收縮素轉化酶 (ACE) 之活性。高劑量的WECF處理使SHR之收縮壓、舒張壓及血漿ACE顯著降低。芸香苷與WECF之降血壓效果相當。存在於WECF中之芸香苷可能參與部分降血壓作用。因此，WECF具有降血壓效果，並且有潛力發展成為輔助調節血壓功能食品之用途。 Hypertension is a major disease that threatens human health worldwide. This study aimed to investigate the antihypertensive effect of Djulis (Chenopodium formosanum) (WECF) and its bioactive compounds, rutin and betanin, in spontaneously hypertensive rats (SHR rats). Ten-week-old SHR rats and Wistar-Kyoto rats (WKY rats) were used in this study. SHR Rats were, respectively, given rutin (50 mg/kg bw), betanin (50 mg/kg bw), and low dose (10 mg/kg bw), medium dose (50 mg/kg bw) and high dose (100 mg/kg bw) of WECF, or captopril (50 mg/kg bw, CA group) for 21 days. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using a Rat Non-Invasive Tail-Cuff Blood Pressure System. Angiotensin converting enzyme (ACE) activity of plasma in rats were determined. High dose of WECF treatment led to significant decrease in systolic, diastolic pressures and ACE activity in the SHR rats. Furthermore, the antihypertensive effect of rutin was comparable with that of WECF. The presence of rutin in WECF may partly be responsible for the antihypertensive effect of WECF. Thus, WECF has antihypertensive effects and can potentially be used as a functional food for hypertension.
Relation:	電子全文公開日期：2022-09-25，學年度：105，120頁
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Dissertations and Theses

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