Application of the Aluminum Reagents in Enantioselective Arylation of Aldehydes

CNU IR > Pharmacy and Science > The 5rh Conference of Channel-bridge Chemistry, Biology and materal Science > Item 310902800/30492

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/30492

题名:	Application of the Aluminum Reagents in Enantioselective Arylation of Aldehydes
作者:	Shuangliu Zhou Han-Mou Gau
贡献者:	Department of Chemistry, National Chung Hsing University
日期:	2008-07
上传时间:	2017-12-04 15:55:34 (UTC+8)
摘要:	The catalytic asymmetric aryl addition of aldehydes has attracted much attention because the chiral diaryl alcohols are important intermediates to many biologically active compounds. After the asymmetric addition of diphenylzinc to aldehyde, the mixed reagnts of Ph2Zn/Et2Zn and arylboronic acid/Et2Zn as aryl sources were developed to improve the enantioselectivity of the aryl transfer. Recently we have reported asymmetric additions of AlAr3 (THF) to aldehydes or ketones catalyzed by the titanium (IV) complexes of (R)-H8-BINOL or (S)-BINL. In this study, we develop a series of arylauminum reagents for asymmetric arylation to aldehydes. The aluminum reagents include AlPh3 (OEt2), AlPh3 (DMAP), AlPh3 (OPPh3), AlEtPh2 (DMAP), AlEtPh2 (OPPh3), and AlEt2Ph (THF). AlEt2Ph (THF) in solution is actually a mixture fo AlET3 (THF), AlEt2Ph (THF), AlEtPh2 (THF) and AlPh3 (THF). Distillation of the above mixture gave AlEt3 (THF) and AlPh3 (THF). The asymmetric additions of the aluminum reagents to 1-naphthaldehyde were studied. Results showed that the supplemental ligands have a strong influence on the reactivity and enantioselectivity in the asymmetric arylation reactions.
關聯:	第五屆海峽化學、生物及材料研討會，起迄日：2008/07/21-2008/07/22，地點：嘉南藥理科技大學
显示于类别:	[Pharmacy and Science] The 5rh Conference of Channel-bridge Chemistry, Biology and materal Science

文件中的档案:

档案	描述	大小	格式	浏览次数
C12.pdf		351Kb	Adobe PDF	318	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....