A New Compound,brefeldin A formylate,from Penicillium sp.Strain HLKG-44

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Title:	A New Compound,brefeldin A formylate,from Penicillium sp.Strain HLKG-44
Authors:	Mei-juan Fang Han-wen Zhang Hong-Ming Cheng Hua Fang Yu-fen Zhao
Contributors:	Department of Pharmaceutical Science, Medical College, Xiamen University Department of Chemistry, Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering The Third Institute of Oceanography of the State Oceanic Adminstration
Date:	2008-07
Issue Date:	2017-12-04 15:54:24 (UTC+8)
Abstract:	Less attention was focused on the fungi which were isolated from polluted environment, which might provide a good alternative to search for useful natural products1.Penicillium sp. Strain HLKG-44 is an endophytic fungus isolated from a highly contaminated river in southern China. The extracts of the fungus show high cytotoxicity against sereval human cancer cell lines , such as KB cell (IC50,0.028 g/ml) and Raji cell(IC50, 0.035 g/ml). Little work has been carried out on the fungal genus, Penicillium.During initial investigations into the metabolites of this species, we have isolated three compounds,including a new compound, named as brefeldin A formylate, and two known compounds , brefeldin A and ergosterol. BFA is a macro-cyclic lactone fungal metabolite exhibiting a wide range of antifungal, antiviral, antimitotic, and antitumor activity2 . It has attracted research interest for many years due to its peculiar molecular structure and its bioactivity3,4. Here, we find brefeldin A fromylate for the first time from penicillum sp. strain HLKG-44. Brefeldin A formylate also shows antitumor activity. In the present paper , we report the isolation and structural elucidation of the new compounds 1, together with two known compounds , brefeldin A and ergosterol. The structure of the compound 1 was established by the spectral X-ray crystallographic analysis (Figure 2)
Relation:	第五屆海峽化學、生物及材料研討會，起迄日：2008/07/21-2008/07/22，地點：嘉南藥理科技大學
Appears in Collections:	[Pharmacy and Science] The 5rh Conference of Channel-bridge Chemistry, Biology and materal Science

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