Synthesis of Novel N-Aryl piperazin2-Aryl-4-Quinolone Phosphonates

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Title:	Synthesis of Novel N-Aryl piperazin2-Aryl-4-Quinolone Phosphonates
Authors:	Chen Xiao-Lan (陳曉嵐) Qu Zhi-bo (屈智博) Qu Ling-Bo (屈凌波) Lu Jian-Sha (盧建莎) Liao Xin-Cheng(廖新成) Zhao Yu-Fen(趙玉芬)
Contributors:	Key Laboratory of Chemical Biology and organic Chemistry,Department of Chemistry, Zhengzhou University Henan Univeue of Techhnology, Henan Province Key Laboratory of Bioorganic Phosphours Chemistry&Chemical Biology,Ministry of Education,Department of Chemistry
Date:	2008-07
Issue Date:	2017-12-04 15:52:25 (UTC+8)
Abstract:	Flavonoids have a wide range of physiological activity, including anticytotoxic, antimitotic, antibacterial, antiplatelet, anti-tumor activities. It is reported that replacement of the O1 of flavonoid by nitrogen would allow the attachment of groups that might give rise to beneficial interactions with the biological active site. Also, the presence of a nitrogen would allow the formation of ammonium salts and therefore to enhance the solubility of the synthesized compounds . 2-aryl-4 - quinolones and related compounds, as a class of aza flavone analogues and cardiovascular protectors, have been extensively studied in the past ten years. Piperazine analogues own many bioactivities. It is an established fact that esters of phosphoric acid have wide bioactivities play a vital role in many biological processes. In order to enhance the physicochemical and biological properties of 2-aryl-4-quinolones and phosphoramide piperazine, we synthesized a series of new phosphoramidate derivatives of 2-aryl-4quinolones (Scheme 1) with hope of increasing tumor selectivity, overcoming tumor resistance and decreasing the toxicity of the compounds. The structures of all the newly synthesized compounds were defined by ESI-MS, NMR and IR.
Relation:	第五屆海峽化學、生物及材料研討會，起迄日：2008/07/21-2008/07/22，地點：嘉南藥理科技大學
Appears in Collections:	[Pharmacy and Science] The 5rh Conference of Channel-bridge Chemistry, Biology and materal Science

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