Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30466
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    Title: A.nidulans 之orsellinic acid/F9775 基因叢集二次代謝物及其衍生物之相關研究 ─ 子計畫三:A.nidulans之orsellinic acid/F9775基因叢集二次代謝物及其衍生物的生物活性分析
    Authors: 洪瑞祥
    Contributors: 生物科技系
    Date: 2010
    Issue Date: 2017-11-29 16:56:53 (UTC+8)
    Abstract: Aspergillus nidulans (A. nidulans)已被當作一個生物體模式來應用於研究基因調節與藥物的研發,包含A. nidulans 的 aspergillus 類之基因體定序後顯示有著豐富的二次代謝基因串,並且過去的研究也發現在A.nidulan 可表現出一些具有醫療價值的二次代謝產物。最近研究以成功的把A. nidulans 的F9775 誘導出orsellinic acid,因為這些二次代謝物都具有高度的醫療價值,所以我們將以此orsellinic acid 來當作骨架來進一步的修飾使得其更具醫療的價值,我們將以成骨及噬骨細胞來討這些orsellinic acid 及其衍生物對細胞毒殺的效應,更進一步的研發出一個具有醫療價值的藥物。
    Relation: 計畫編號:CN9911;計畫年度:99
    Appears in Collections:[Dept. of Biotechnology (including master's program)] Chna Project

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