English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17776/20117 (88%)
Visitors : 11034030      Online Users : 502
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30449

    標題: 化妝品與生髮製品中minoxidil 測定方法之研究
    Determination of Minoxidil in Hair Care Cosmetic and Hair Growth Pharmaceutical Products
    作者: 王來好
    貢獻者: 醫藥化學系
    關鍵字: 分子印跡聚合物
    molecularly imprinted polymer
    metal nanoparticals
    日期: 2016
    上傳時間: 2017-11-27 09:55:43 (UTC+8)
    摘要: 本計畫製備一個電化學感測器,是基於電聚合成分子印跡聚合物- minoxidil-金屬奈米粒子膜在玻碳電極 (metal NPs/ MX-MIP/GCE)。本計畫研究目的是找到最好的聚合條件,幾個變數包括支持電解質種類、pH 值、單體的莫爾比、施加的電位、掃瞄次數和速率、選擇適當的溶劑以移除模板分子 (minoxidil )等。利用掃描電子顯微鏡 (SEM )、循環伏安法(CV)與電化學交流阻抗光譜法 ( EIS) 研究修飾電極的表面特徵。評估各種型式的分子印跡聚合物修飾電極在感測器,對minoxidil 的靈敏度、 穩定性、再現性及選擇性。將感測器應用於實際市售化妝品和藥品中minoxidil 的含量測定。同時利用高效率液相層析連線光二極體陣列檢測器做比較。
    In this project, a electrochemical sensor based on minoxidil molecularly imprinted polymer (MIP)- metal nanoparticals film on a glassy carbon electrode (metal NPs/ MX-MIP/GCE) is fabricated. The objectives of this project is to find the best polymerization conditions, several variables including the kind of supporting electrolytes, pH, mole ratio of monomers, applied potential, scan number and rate and selection of suitable solvent for template (minoxidil) removal are studied. The resulted modified electrode is characterized of surface feature by scanning electron microscopic (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). This project also evaluates various modified carbon electrodes, as well as analysis of the sensitivity, stability, reproducibility, and selectively of sensors in investigation of minoxidil. The sensor is applied for the determination of minoxidil in real commercial cosmetic and drug products, and compared to high – performance liquid chromatography with photodiode array detection.
    關聯: 計畫編號:MOST105-2113-M041-001
    Appears in Collections:[醫藥化學系 ] 科技部計畫

    Files in This Item:

    File Description SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback