| 摘要: | 青春痘為人體皮膚容易發生的癥兆，市售抗菌清潔用品一般添加三氯沙等殺菌化學成分。如果能運用天然素材取代化學藥劑，將會降低化學藥劑對肌膚造成已知或未知的傷害。本研究探討16種植物萃取液(包括五倍子、連翹、艾草、蘇木、夏枯草、仙鶴草、咸豐草、金銀花、魚腥草、黃柏、左手香、虎杖、黃芩、大黃、紫蘇及苦參)，組合具抑菌效果之複合性萃取液，並尋求具效益的手工皂製程，進一步將此萃取液入皂，期望能研發具經濟效能的抑菌手工皂。研究結果發現，咸豐草、蘇木、五倍子、黃柏、黃芩及大黃，對痤瘡桿菌及金黃色葡萄球菌均具抑制能力；將其進行隨機組合為No.1～No.16（16種）複合性植物萃取液，發現其中8種複合性萃取液對痤瘡桿菌均具高度抑制活性，對照複合組合成分發現，組合樣本No.4對抑制痤瘡桿菌具協同抑菌作用。16種複合萃取液中有5種複合性萃取液對金黃色葡萄球菌具高度抑制活性。手工皂製程以方法A（全程50℃控溫，鹼液平均分四次，每次四分之一量，倒入油中以攪拌機製作）之方式，製作手工皂外觀細緻度最好，且製作時間比一般手持式攪拌器縮短約1/3。將複合性植物萃取液入皂，採用方法A方式製作，發現手工皂添加油量7%的No.7複合性植物萃取液，其抑制痤瘡桿菌及金黃色葡萄球菌之能力均優於市售添加三氯沙之抗菌香皂，是可考慮研發為具經濟效能的抑菌手工皂。
The objective of this research is to provide multiple herbal extracts based on 16 different herbs (including Melaphis chinensis, Forsythia suspensa, Artemisia argyi, Caesalpinia sappan, Prunella vulgaris, Agrimonia pilosa , Bidens pilosa, Lonicera japonica, Houttuynia cordata, Phellodendron chinense, Pogostemon cabin, Polygonum cuspidatum, Scutellaria baicalensis, Rheum palmatum, Perilla frutescens, and Sophora flavescens) and demonstrate their inhibitory effects on Propionibacterium acnes. Furthermore, applying these multiple herbal extracts into handmade soaps coordinated with efficiency methods of soap making in order to develop commercially anti-bacterial handmade soaps. The results showed that extracts of Melaphis chinensis, Caesalpinia sappan, Bidens pilosa, Phellodendron chinense, Scutellaria baicalensis, and Rheum palmatum significantly suppressed both P. acnes and Staphylococcus aureus. These extracts were randomly combined into 16 kinds of multiple extracts, marked as No.1~No.16. It turned out that 8 kinds of multiple extracts had strong inhibitory activities on P. acnes. Among all, No.4 extract had a synergistic effect on inhibiting P. acnes. Moreover, 5 kinds of multiple extracts had strong inhibitory activities on S. aureus. In this study, the soap making process, method A (produced with a laboratory stirrer under 50℃, divided lye into four equal amounts and applied a quarter at a time), was proved to provide handmade soaps the most meticulous surface. In addition, it decreased the production time by 1/3 compared to producing with manual mixer. Applied multiple herbal extracts into handmade soaps and produced with method A, we found that soaps with No.7 extract added had superior inhibition on both P. acnes and S. aureus than commercial triclosan soaps, and had the potential to develop into commercially anti-bacterial handmade soaps. |
