創傷弧菌 (Vibrio vulnificus) 是一種藉由傷口或食入受此菌汙染之海鮮的一種人類伺機性致病菌，會造成嚴重的皮膚損傷與敗血症。其人體被創傷弧菌感染後，發病病程相當快速約入院後 2-3 天死亡，死亡率高達 50%。因此，本論文的目標將探討台灣、美國、日本、韓國、中國等國家近十年來患者的特性與致死率。 回顧國內外有關創傷弧菌的文獻資料，創傷弧菌感染盛行的月份主要於夏季，以四月至十月期間是感染率的高峰期且與海水溫度有高度相關性。再者，人類感染創傷弧菌的臨床症狀則是以原發性敗血症的致死率最高，男性比女性有較高的感染盛行率，且易發生在中高年齡的人。近十年來治療創傷弧菌感染的抗生素藥物已有所改變，目前氟?諾酮類 (quinolone) 加上第三代頭孢子菌素 (3rd generationcephalosporin) 與四環黴素 (tetracycline) 是治療創傷弧菌感染最好的抗生素策略。 Vibrio vulnificus is a halophilic gram-negative pathogen that infections through open wound or contaminated seafood, can cause serious skin damage and sepsis. Clinical symptoms are primary septicemia, wound infection, and gastrointestinal discomfort. This study is to investigate primary septicemia and wound infection of demographic data and mortality in Taiwan, United States, Japan, South Korea, and China. V. vulnificus infection mainly occused the summer during April to October in Japan and Taiwan, and highly correlated with increased seawater temperatures. The primary septicemia that a significant higher mortality compared to those with wound infection. In prensent, among the classes of antibiotics fluoroquinolone plus a third-generation cephalosporin and tetracycline are effective against V. vulnificus infection.
