Therapeutic ultrasound suppresses neuropathic pain and upregulation of substance p and neurokinin-1 receptor in rats after peripheral nerve injury

doi:10.1016/j.ultrasmedbio.2014.07.022

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標題:	Therapeutic ultrasound suppresses neuropathic pain and upregulation of substance p and neurokinin-1 receptor in rats after peripheral nerve injury
作者:	Chen, Yu-Wen Tzeng, Jann-Inn Huang, Po-Ching Hung, Ching-Hsia Shao, Dong-Zi Wang, Jhi-Joung
貢獻者:	食品科技系
關鍵字:	Therapeutic ultrasound Neuropathic pain Substance P Neurokinin-1 receptor Tumor necrosis factor α Interleukin-6
日期:	2015-01
上傳時間:	2016-04-19 19:07:12 (UTC+8)
出版者:	Elsevier Science Inc
摘要:	We studied the mechanisms and impact of therapeutic ultrasound (TU) for pain caused by nerve injury. TU began on post-operative day 5 (POD5) and then continued daily for the next 22 d. Sensitivity to thermal and mechanical stimuli and levels of neurokinin-1 receptor, substance P, tumor necrosis factor-alpha and interleukin-6 in the sciatic nerve were examined. On POD7, chronic constriction injury rats undergoing TU at an intensity of 1 W/cm(2), but not 0.25 or 0.5 W/cm(2), had increases in both the mechanical withdrawal threshold and the thermal withdrawal latency compared with the chronic constriction injury group. Moreover, chronic constriction injury rats exhibited upregulation of neurokinin-1 receptor, substance P, tumor necrosis factor-alpha and interleukin-6 in the sciatic nerve on PODs 14 and 28, whereas TU inhibited their increased expression. We suggest that the efficacy of TU is dependent on its ability to limit the upregulation of neurokinin-1 receptor, substance P, tumor necrosis factor-alpha and interleukin-6 around the injured sciatic nerve. (E-mail: chhung@mail.ncku.edu.tw) (C) 2015 World Federation for Ultrasound in Medicine & Biology.
關聯:	Ultrasound In Medicine And Biology, v.41 n.1, pp.143-150
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