Chemical characteristics and anti-proliferation activities of Ganoderma tsugae polysaccharides

doi:10.1016/j.carbpol.2015.03.088

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/29757

Title:	Chemical characteristics and anti-proliferation activities of Ganoderma tsugae polysaccharides
Authors:	Chien, Rao-Chi Yen, Ming-Tsung Tseng, Yu-Hsiu Mau, Jeng-Leun
Contributors:	生活應用與保健系
Keywords:	Ganoderma tsugae Polysaccharide Anti-proliferation
Date:	2015-09
Issue Date:	2016-04-19 19:07:06 (UTC+8)
Publisher:	Elsevier Sci Ltd
Abstract:	Polysaccharides were extracted by hot-water and hot-alkali from four forms of Ganoderma tsugae including mature and baby Ling chih, mycelium and filtrate. Different profiles of proximate composition and monosaccharide constituents, and element contents were found in the extracted polysaccharides from different extractions and different forms. The molecular weight distributions of polysaccharides were 2.8 x 10(4)-6.5 x 10(5) Da and their infrared spectra were comparable. The hot-alkali extracted polysaccharides exhibited better anti-proliferation on IMR32 cells than the hot-water extracted polysaccharides, which were in turn more effective than the hot-water extracts. Besides, most hot-water extracts and both extracted polysaccharides exhibited an anti-proliferation effect on Hep G2 cells. However, the hot-water extracts showed less effective in anti-proliferation of IMR32 and Hep G2 cells. Based on the anti-tumor effects, both polysaccharides could be prepared for use in the formulation of nutraceuticals and functional foods. (C) 2015 Elsevier Ltd. All rights reserved.
Relation:	Carbohydrate Polymers, v.128, pp.90-98
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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