Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29725
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    標題: Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy
    作者: Liao, Hung-Wei
    Hung, Peir-Haur
    Hsiao, Chih-Yen
    Liou, Hung-Hsiang
    Lin, Hsin-Shih
    Huang, Tsang-Hai
    Jou, I-Ming
    Tsai, Kuen-Jer
    貢獻者: 生活應用與保健系
    關鍵字: in-vivo
    Secondary hyperparathyroidism
    Renal hyperparathyroidism
    Circulating levels
    gene-expression
    Oral phosphate
    Mousemodel
    Hormone
    fgf23
    fgf-23
    日期: 2015-07
    上傳時間: 2016-04-19 19:05:59 (UTC+8)
    出版者: Public Library Science
    摘要: Background
    Phosphate burden in chronic kidney disease (CKD) leads to elevated serum fibroblast factor-23 (FGF-23) levels, secondary hyperparathyroidism and chronic kidney disease-mineral bone disorder (CKD-MBD). However dissociated hyperphosphatemia and low serum FGF-23 concentrations have been observed in experimentally parathyoridectomized rats. The relationships between serum mineral, hormone, and bone metabolism may be altered in the presence of CKD. The aim of our study was to investigate whether a consistent relationship existed between serum FGF-23 levels, specific serum biochemical markers, and histomorphometric parameters of bone metabolism in a parathyroidectomized CKD animal model.
    Results
    Sprague Dawley rats were divided into 3 groups: parathyroidectomy (PTX) and CKD (PTX+CKD, 9 rats), CKD without PTX (CKD, 9 rats), and neither PTX nor CKD (sham-operated control, 8 rats); CKD was induced by partial nephrectomy. At 8 weeks after partial nephrectomy, serum biomarkers were measured. Bone histomorphometries of the distal femoral metaphyseal bone were analyzed. The mean serum FGF-23 levels and mean bone formation rate were the highest in the CKD group and the lowest in the PTX+CKD group. Bone volume parameters increased significantly in the PTX+CKD group. Pearson's correlation revealed that serum FGF-23 levels associated with those of intact parathyroid hormone, phosphate, collagen type I C-telopeptide, and calcium. Univariate linear regression showed that serum FGF-23 values correlated with bone formation rate, bone volume, and osteoid parameters. Stepwise multivariate regression analysis revealed that circulating FGF-23 values were independently associated with bone volume and thickness (beta = -0.737; p < 0.001 and beta = -0.526; p = 0.006, respectively). Serum parathyroid hormone levels independently correlated with bone formation rate (beta = 0.714; p < 0.001) while collagen type I C-telopeptide levels correlated with osteoid parameter.
    Conclusion
    Serum FGF-23 levels independently correlated with bone volume parameters in rats with experimentally induced CKD.
    關聯: Plos One, v.10 n.7, Article ID e0133278
    显示于类别:[生活應用與保健系] 期刊論文

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