Clinical Manifestations of Non-01 Vibrio cholerae Infections

doi:10.1371/journal.pone.0116904

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/29717

Title:	Clinical Manifestations of Non-01 Vibrio cholerae Infections
Authors:	Chen, Yen-Ting Tang, Hung-Jen Chao, Chien-Ming Lai, Chih-Cheng
Contributors:	保健營養系
Keywords:	Cirrhotic patient United-states Septicemia Cholecystitis Abscess
Date:	2015-01
Issue Date:	2016-04-19 19:05:43 (UTC+8)
Publisher:	Public Library Science
Abstract:	Background Infections caused by non-01 Vibrio cholera are uncommon. The aim of our study was to investigate the clinical and microbiological characteristics of patients with non-01 V. cholera infections. Methods The clinical charts of all patients with non-01 V. cholera infections and who were treated in two hospitals in Taiwan were retrospectively reviewed. Results From July 2009 to June 2014, a total of 83 patients with non-01 V. cholera infections were identified based on the databank of the bacteriology laboratories of two hospitals. The overall mean age was 53.3 years, and men comprised 53 (63.9%) of the patients. Liver cirrhosis and diabetes mellitus were the two most common underlying diseases, followed by malignancy. The most common type of infection was acute gastroenteritis (n = 45, 54.2%), followed by biliary tract infection (n = 12, 14.5%) and primary bacteremia (n = 11, 13.3%). Other types of infection, such as peritonitis (n = 5, 6.0%), skin and soft tissue infection (SSTI) (n = 5, 6.0%), urinary tract infection (n = 3, 3.6%) and pneumonia (2, 2.4%), were rare. July and June were the most common months of occurrence of V. cholera infections. The overall in-hospital mortality of 83 patients with V. cholera infections was 7.2%, but it was significantly higher for patients with primary bacteremia, hemorrhage bullae, acute kidney injury, acute respiratory failure, or admission to an ICU. Furthermore, multivariate analysis showed that in-hospital mortality was significantly associated with acute respiratory failure (odds ratio, 60.47; 95% CI, 4.79-763.90, P = 0.002). Conclusions Non-01 V. cholera infections can cause protean disease, especially in patients with risk factors and during warm-weather months. The overall mortality of 83 patients with non-01 V. cholera infections was only 7.2%; however, this value varied among different types of infection.
Relation:	Plos One, v.10 n.1,Article ID e0116904
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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