Characterization and in vitro biocompatibility of catanionic assemblies formed with oppositely charged dicetyl amphiphiles

doi:10.1016/j.colsurfb.2014.12.007

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/29706

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標題:	Characterization and in vitro biocompatibility of catanionic assemblies formed with oppositely charged dicetyl amphiphiles
作者:	Liang, Chia-Hua Yeh, Li-Hsien Liao, Pei-Wen Chou, Tzung-Han
貢獻者:	化粧品應用與管理系
關鍵字:	Cytotoxicity Self-assembly Phase behavior Membrane fluidity Drug delivery
日期:	2015-02
上傳時間:	2016-04-19 19:05:19 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	In this study, cationic dicetyldimethylammonium bromide (DCB) and anionic dicetyl phosphate (DCP) were mixed to form catanionic assemblies in water, and their colloidal morphology, size, charge characteristics, phase behavior, membrane fluidity, and in vitro biocompatibility are comprehensively investigated for the first time. Our results show that the catanionic DCB and DCP mixtures in water are capable of forming circular vesicles and this binary mixed system expresses the miscibility with deviation from the ideal mixing. Compared to the nanoscale DCB-rich vesicles, the DCP-rich vesicles have smaller size, higher negative zeta potential, higher main transition temperature, and better storage stability. The temperature and molecular cooperativity of the main transition phase for the DCP vesicles can be reduced by an addition of DCB. This work demonstrates that the head groups and the relative composition of the two considered dicetyl amphiphiles remarkably affect the phase behavior, membrane rigidity, encapsulation ability and in vitro biocompatibility of DCB/DCP vesicles. The iso-stoichiometric mixed DCB/DCP vesicle, showing low cytotoxicity, long storage time, and high drug loading, is a potential candidate for the drug delivery system
關聯:	Colloids And Surfaces B-Biointerfaces, v.126, pp.10-17
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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