Risk of Shingles in Adults with Primary Sjogren's Syndrome and Treatments: A Nationwide Population-Based Cohort Study

doi:10.1371/journal.pone.0134930

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標題:	Risk of Shingles in Adults with Primary Sjogren's Syndrome and Treatments: A Nationwide Population-Based Cohort Study
作者:	Chen, Jen-Yin Wang, Li-Kai Feng, Ping-Hsun Chu, Chin-Chen Cheng, Tain-Junn Weng, Shih-Feng Wu, Su-Zhen Lu, Tsung-Hsueh Chang, Chia-Yu
貢獻者:	老人服務事業管理系
關鍵字:	Herpes-zoster Postherpetic neuralgia Rheumatoid-arthritis Classification criteria Nutritional factors Complication rates United-kingdom Peptic-ulcer Vitamin-C Vaccination
日期:	2015-08
上傳時間:	2016-04-19 19:05:11 (UTC+8)
出版者:	Public Library Science
摘要:	Background Primary Sjogren's syndrome (pSS) is associated with immunological dysfunctions-a well-known risk factor of shingles. This study aimed to examine the incidence and risk of shingles in adults with pSS and pharmacological treatments. Methods This retrospective population-based cohort study was conducted using National Health Insurance claims data. Using propensity scores, 4,287 pSS adult patients and 25,722-matched cohorts by age, gender, selected comorbidities and Charlson comorbidity index scores were identified. Kaplan-Meier analysis and Cox regression were conducted to compare the differences in developing shingles. In pSS, oral and eye dryness are treated with substitute agents. Extraglandular features are often treated with pharmacological drugs including steroids and immunosuppressants. pSS patients were grouped as follows: no pharmacological drugs, steroids alone; immunosuppressants alone; combined therapies. Results During the follow-up, 463 adults with pSS (10.80%) and 1,345 control cohorts (5.23%) developed shingles. The cumulative incidence of shingles in pSS patients (18.74/1,000 patient-years) was significantly higher than controls (8.55/1,000 patient-years). The adjusted hazard ratio (HR) of shingles was 1.69 (95% confidence interval (CI) 1.50-1.90). In age-subgroup analyses, incidences of shingles in pSS increased with age and peaked in pSS patients aged. 60; however, adjusted HRs decreased with age. Compared to control cohorts with no drugs, adjusted HRs for shingles in pSS patients were ranked from high to low as: combined therapies (4.14; 95% CI 3.14-5.45) > immunosuppressants alone (3.24; 95% CI 2.36-4.45) > steroids alone (2.54; 95% CI 2.16-2.97) > no pharmacological drugs (2.06; 95% CI 1.76-2.41). Rates of shingles-associated hospitalization and postherpetic neuralgia were 5.62% and 24.41%, both of which were significantly higher than those (2.60%; 13.01%) in the control cohorts. Conclusions Adults with pSS were at greater risk for shingles than control cohorts. Drug exposures significantly increased the risk of shingles in pSS.
關聯:	Plos One, v.10 n.8, Article ID e0134930
Appears in Collections:	[高齡福祉養生管理系] 期刊論文

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