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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29692


    標題: Possible Mechanisms of Di(2-ethylhexyl) Phthalate-Induced MMP-2 and MMP-9 Expression in A7r5 Rat Vascular Smooth Muscle Cells
    作者: Shih, Mei-Fen
    Pan, Kuang-Hung
    Cherng, Jong Yuh
    貢獻者: 藥學系
    關鍵字: di(2-ethylhexyl) phthalate (DEHP)
    vascular smooth muscle cells (VSMC)
    MMP-2
    MMP-9
    p38 MAPK
    ERK1/2
    Akt
    NF-κB
    日期: 2015-12
    上傳時間: 2016-04-19 19:04:49 (UTC+8)
    出版者: Mdpi Ag
    摘要: Proliferation and migration of vascular smooth muscle cells (VSMC) are important in the development and/or progression of many cardiovascular diseases, including atherosclerosis. Evidence shows that matrix metalloproteinase (MMP)-2 and MMP-9 are related to the pathogenesis of atherosclerosis. The expressions of MMP-2 and MMP-9 in atherosclerosis are regulated via various pathways, such as p38 mitogen activated protein kinase (MAPK), extracellular signal regulated kinase 1 and 2 (ERK1/2), Akt, and nuclear factor kappa (NF-kappa B). Di(2-ethylhexyl) phthalate (DEHP) has been shown to induce atherosclerosis by increasing tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and intercellular adhesion molecule (ICAM) productions. However, whether DEHP poses any effects on MMP-2 or MMP-9 expression in VSMC has not yet been answered. In our studies, rat aorta VSMC was treated with DEHP (between 2 and 17.5 ppm) and p38 MAPK, ERK1/2, Akt, NF-kappa B, and MMP-2 and MMP-9 proteins and activities were measured. Results showed that the presence of DEHP can induce higher MMP-2 and MMP-9 expression than the controls. Similar results on MMP-regulating proteins, i.e., p38 MAPK, ERK1/2, Akt, and NF-kappa B, were also observed. In summary, our current results have showed that DEHP can be a potent inducer of atherosclerosis by increasing MMP-2 and MMP-9 expression at least through the regulations of p38 MAPK, ERK1/2, Akt, and NF-B.NF-kappa B.
    關聯: International Journal of Molecular Sciences, v.16 n.12, pp.28800-28811
    Appears in Collections:[藥學系(所)] 期刊論文

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