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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29667


    標題: Effect of metformin on the incidence of head and neck cancer in diabetics
    作者: Yen, Yung-Chang
    Lin, Charlene
    Lin, Shih-Wei
    Lin, Yung-Song
    Weng, Shih-Feng
    貢獻者: 醫務管理系
    關鍵字: head and neck cancer
    oral cancer
    nasopharyngeal carcinoma
    diabetes
    metformin
    日期: 2015-09
    上傳時間: 2016-04-19 19:03:55 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: BackgroundThe purpose of this study was to examine the effect of metformin on head and neck cancer in patients with diabetes.
    MethodsWe compared 66,600 patients, all with diabetes and all newly diagnosed with head and neck cancer in 2002. Half were being treated with metformin for diabetes (Met(+)) and half were not (Met(-): controls). All were matched for comorbidities (obesity, coronary artery disease, hyperlipidemia, and hypertension), sex, and age. The risk of head and neck cancer at the end of 2011 was determined.
    ResultsThe incidence of head and neck cancer was 34% lower in the Met(+) cohort than in the Met(-) cohort (adjusted hazard ratio [HR]=0.66; 95% confidence interval [CI]=0.55-0.79). The risks for oropharyngeal cancer (adjusted HR=0.66; 95% CI=0.17-0.74) and nasopharyngeal carcinoma (NPC; adjusted HR=0.50; 95% CI=0.31-0.80) were significantly lower in the Met(+) cohort than in the Met(-) cohort
    關聯: Head And Neck-Journal For The Sciences And Specialties of The Head And Neck, v.37 n.9, pp.1268-1273
    Appears in Collections:[醫務管理系(所)] 期刊論文

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