Epidemiology and prognostic factors of candidemia in elderly patients

doi:10.1111/ggi.12329

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/29638

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標題:	Epidemiology and prognostic factors of candidemia in elderly patients
作者:	Tang, Hung-Jen Liu, Wei-Lun Lin, Hsin-Lan Lai, Chih-Cheng
貢獻者:	保健營養系
關鍵字:	cancer candida albicans candidemia elderly outcome
日期:	2015-06
上傳時間:	2016-04-19 19:02:54 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	AimThe present retrospective study was carried out to investigate the epidemiological characteristics and the prognostic factors of candidemia among elderly patients.MethodsFrom 2009 to 2012, elderly patients with candidemia were identified at the Chi Mei medical center, a 900-bed regional hospital in southern Taiwan, and their medical records retrospectively reviewed.ResultsDuring the 4-year period, a total of 175 episodes of candidemia among elderly patients were identified. The patients ranged in age from 65 to 98years (mean 76.4years) and the mean (standard deviation) Charlson Comorbidity Index score was 7.6 (+/- 2.7). Cancer was the most common underlying disease (n=127, 72.6%), followed by diabetes mellitus (n=69, 39.4%). Candida albicans (n=96, 54.9%) was the most common pathogen, followed by C.tropicalis (n=39, 22.3%), C.parapsilosis (n=24, 13.7%), C.glabrata (n=22, 12.6%), C.guilliermondii (n=2, 1.1%) and Candida species (n=3, 1.7%). The ratio of C.albicans causing candidemia was significantly higher in young-old than old-old patients (64.1% vs 47.4%, P=0.027). The overall in-hospital mortality was 50.3%. Multivariate analysis showed that the in-hospital mortality was only significantly associated with jaundice (P=0.004), no use of antifungal agent (P=0.021) and intensive care unit admission (P<0.001).ConclusionsCandidemia can develop in elderly patients, especially patients with cancer or other risk factors. C.albicans is the most common Candida species causing candidemia among elderly patients, followed by C.tropicalis. The mortality of candidemia among elderly patients remains high. Geriatr Gerontol Int 2015; 15: 688-693.
關聯:	Geriatrics & Gerontology International, v.15 n.6, pp.688-693
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