Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29637
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 17773/20058 (89%)
造訪人次 : 8938343      線上人數 : 475
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/29637


    標題: Clonidine intensifies memantine cutaneous analgesia in response to local skin noxious pinprick in the rat
    作者: Wu, Bor-Tsang
    Chen, Kuan-Ting
    Liu, Kuo-Sheng
    Chen, Yu-Wen
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: 藥學系
    關鍵字: Clonidine
    Memantine
    Lidocaine
    Infiltrative cutaneous analgesia
    日期: 2015-06
    上傳時間: 2016-04-19 19:02:52 (UTC+8)
    出版者: Polish Acad Sciences Inst Pharmacology
    摘要: Background: The purposes of this study were to evaluate the co-administration of clonidine with memantine and to determine whether it has a peripheral action in intensifying cutaneous analgesia.Methods: Cutaneous analgesia was examined through inhibition of the cutaneous trunci muscle reflex in response to the local noxious pinprick in rats. Effect of the added subcutaneous clonidine to memantine on infiltrative cutaneous analgesia was assessed and compared with the local anesthetic lidocaine.Results: On the 50% effective dose (ED50) basis, the rank of drug potency was memantine [4.05 (3.95-4.18) mu mol] > lidocaine [5.81 (5.70-5.98) mu mol] (p < 0.01). Clonidine at a dose of 0.12 mu mol did not elicit cutaneous analgesia. Mixtures of clonidine (0.12 mu mol) with drug (memantine or lidocaine) at ED50 or ED95 prolonged the duration of action and enhanced the potency as infiltrative cutaneous analgesia. Clonidine enhanced the lidocaine cutaneous analgesia in which had a better effect than added to memantine.Conclusions: Our resulting data showed that memantine displayed more potent cutaneous analgesia than lidocaine. Co-administration of memantine or lidocaine with clonidine increased the potency and duration of the cutaneous analgesia. Clonidine intensified the effects of lidocaine promoting cutaneous analgesia than added to memantine. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.
    關聯: Pharmacological Reports, v.67 n.3, pp.485-489
    顯示於類別:[藥學系(所)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML413檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋