Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer

doi:10.3892/or.2014.3556

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/29590

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/29590

题名:	Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer
作者:	Shan, Yan-Shen Hsu, Hui-Ping Lai, Ming-Derg Yen, Meng-Chi Luo, Yi-Pey Chen, Yi-Ling
贡献者:	生物科技系老人服務事業管理系
关键词:	gastri ccancer recurrence-free survival argininosuccinate synthetase
日期:	2015-01
上传时间:	2016-04-19 19:01:17 (UTC+8)
出版者:	Spandidos Publ Ltd
摘要:	Aberrant expression of argininosuccinate synthetase (ASS1, also known as ASS) has been found in cancer cells and is involved in the carcinogenesis of gastric cancer. The aim of the present study was to investigate the level of ASS expression in human gastric cancer and to determine the possible correlations between ASS expression and clinicopathological findings. Immunohistochemistry was performed on paraffin-embedded tissues to determine whether ASS was expressed in 11 of 11 specimens from patients with gastric cancer. The protein was localized primarily to the cytoplasm of cancer cells and normal epithelium. In the Oncomine cancer microarray database, expression of the ASS gene was significantly increased in gastric cancer tissues. To investigate the clinicopathological and prognostic roles of ASS expression, we performed western blot analysis of 35 matched specimens of gastric adenocarcinomas and normal tissue obtained from patients treated at the National Cheng Kung University Hospital. The ratio of relative ASS expression (expressed as the ASS/-actin ratio) in tumor tissues to that in normal tissues was correlated with large tumor size (P=0.007) and with the tumor, node, metastasis (TNM) stage of the American Joint Committee on Cancer staging system (P=0.031). Patients whose cancer had increased the relative expression of ASS were positive for perineural invasion and had poor recurrence-free survival. In summary, ASS expression in gastric cancer was associated with a poor prognosis. Further study of mechanisms to silence the ASS gene or decrease the enzymatic activity of ASS protein has the potential to provide new treatments for patients with gastric cancer.
關聯:	Oncology Reports, v.33 n.1, pp.49-57
显示于类别:	[Dept. of Senior Service and Health Management] Periodical Articles [Dept. of Biotechnology (including master's program)] Periodical Articles

文件中的档案:

档案	描述	大小	格式	浏览次数
29590.pdf		548Kb	Adobe PDF	472	检视/开启
index.html		0Kb	HTML	1913	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....