Risk Factors for Development of Septic Shock in Patients with Urinary Tract Infection

doi:10.1155/2015/717094

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標題:	Risk Factors for Development of Septic Shock in Patients with Urinary Tract Infection
作者:	Hsiao, Chih-Yen Yang, Huang-Yu Chang, Chih-Hsiang Lin, Hsing-Lin Wu, Chao-Yi Hsiao, Meng-Chang Hung, Peir-Haur Liu, Su-Hsun Weng, Cheng-Hao Lee, Cheng-Chia Yen, Tzung-Hai Chen, Yung-Chang Wu, Tzu-Chin
貢獻者:	醫務管理系生活應用與保健系
關鍵字:	Acute-renal-failure Acute kidney injury Acute pyelonephritis Severe sepsis Cardiac dysfunction Epidemiology Multicenter Management Mechanisms Mortality
日期:	2015
上傳時間:	2016-04-19 19:00:35 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	Introduction. Severe sepsis and septic shock are associated with substantial mortality. However, few studies have assessed the risk of septic shock among patients who suffered from urinary tract infection (UTI). Materials and Methods. This retrospective study recruited UTI cases from an acute care hospital between January 2006 and October 2012 with prospective data collection. Results. Of the 710 participants admitted for UTI, 80 patients (11.3%) had septic shock. The rate of bacteremia is 27.9%; acute kidney injury is 12.7%, and the mortality rate is 0.28%. Multivariable logistic regression analyses indicated that coronary artery disease (CAD) (OR: 2.521, 95% CI: 1.129-5.628, P = 0.024), congestive heart failure (CHF) (OR: 4.638, 95% CI: 1.908-11.273, P = 0.001), and acute kidney injury (AKI) (OR: 2.992, 95% CI: 1.610-5.561, P = 0.001) were independently associated with septic shock in patients admitted with UTI. In addition, congestive heart failure (female, OR: 4.076, 95% CI: 1.355-12.262, P = 0.012; male, OR: 5.676, 95% CI: 1.103-29.220, P = 0.038, resp.) and AKI (female, OR: 2.995, 95% CI: 1.355-6.621, P = 0.007; male, OR: 3.359, 95% CI: 1.158-9.747, P = 0.026, resp.) were significantly associated with risk of septic shock in both gender groups. Conclusion. This study showed that patients with a medical history of CAD or CHF have a higher risk of shock when admitted for UTI treatment. AKI, a complication of UTI, was also associated with septic shock. Therefore, prompt and aggressive management is recommended for those with higher risks to prevent subsequent treatment failure in UTI patients.
關聯:	Biomed Research International, v.2015, Article ID 717094
顯示於類別:	[醫務管理系(所)] 期刊論文 [生活保健科技系] 期刊論文

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