本研究主要是以熱感應性的Poly(N-isopropylacrylamide-co-N-methylol acrylamide (poly(NIPAAm-NMA))高分子材料及魚鱗胜?做為材料，並使用特殊的紡絲技術將此二種材料製備成電紡纖維，在此研究中，我們改變紡絲條件以及進料的成分比率，探討不同的實驗變因對於電紡纖維形態結構的影響，此外，而為了使電紡纖維的結構穩定，因而在此研究中，利用熱烘的方式將熱感應性的poly(NIPAAm-NMA)高分子材料交聯固定，此外並分別使用戊二醛與1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) 對電紡纖維中的胜?結構進行交聯固定，而後將具交聯結構的電紡纖維進行耐水性實驗，藉由耐水性實驗來評估戊二醛與EDC穩定胜?結構的效率。接著我們以電紡纖維做為載體，分別以直接紡絲以及含浸載負藥物的方式將藥物載入電紡纖維中，並觀察不同的載藥方式對於藥物釋放速率的影響。 In this study, the thermo-sensitive Poly(N-isopropylacrylamide-co-N-methylol acrylamide (poly(NIPAAm-NMA)) and fish peptide were used as materials to manufacture the electrospun fibers by the method of electrospinning. The effects of various variables on the morphology of electrospun fibers were investigated. In order to stabilize the morphology of the electrospun fibers, the poly(NIPAAm) segments were crosslinked by heating process, and the glutaraldehyde and1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) were used to crosslinked the peptide segments respectively. Moreover, the electrospun fibers were used as drug carriers to load with the model drug, caffeine. The caffeine was loaded into the electrospun fibers by the method of swelling process and electrospinning process respectively. The effect of loading methods on the caffeine release rate was investigated.
