本研究住要探討含D-泛醇微乳液配方之物理性質，皮膚的吸收率和形態學特性。其主要成分是不飽和磷脂質(EM 200)，表面活性劑，酒精和D-泛醇。另外在微乳液中添加硬脂胺（SA），使其正電荷進行研究。 結果表明，D-泛醇及硬脂胺在微乳液中最穩定的添加量分別為2％和0.3％，經由一個月的安定性測試結果顯示微乳液配方在酸性條件下比起其它配方更為穩定：在總量方面，各配方經放置四周後總量皆無變化。 皮膚吸收的研究表明，含D-泛醇微乳液未添加電荷物質和添加正電荷物質的皮膚吸收分別為102μg和107μg，明顯比傳統的乳液（37μg）大。這個結果表明微乳液對於皮膚吸收具極大好處。 採用掃描電子顯微鏡進行觀察微乳液處理過的皮膚的形態顯示。經由微乳液處理後皮膚差距比傳統乳液大。 This study is to evaluate the properties of microemulsion containing D-Panthenol including physical properties, skin absorption efficiency and morphology. The main components are unsaturated phospholipid Epikuron(EM 200), surfactant, alcohol and D-Panthenol. The addition of steay amine (SA) in the microemulsion to make positive charge is also studied. The result showed that the maximum addition of D-Panthenol and steayl amine for stable emulsion is 2% and 0.3% respectively. The microemulsions at acidic neutral condition were better stable than at basic condition after one month storage. The amount of D-Panthenol were not charge after one month storage. The skin absorption study showed that the skin absorption of D-Panthenol in uncharge and positive charge microemulsion are 102 ?g and 107?g respectively, which are large than conventional emulsion(37 ?g). This result showed the great benefit of microemulsion. The morphology of the treated skins were also observed by scanning electron microscope. The gap of skins treated by microemulsion are large than conventional emulsion.
