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https://ir.cnu.edu.tw/handle/310902800/28728
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| 標題: | trans-10,cis-12 Conjugated linoleic acid specifically increases tissue alpha-tocopherol mediated by PPAR gamma inhibition in mice |
| 作者: | Wang, Ming-Shyong
Chang, Chia-Ling
Lee, Chien-I
Shaw, Huey-Mei |
| 貢獻者: | 保健營養系 |
| 關鍵字: | alpha-tocopherol
conjugated linoleic acid
mice
rosiglitazone
triglyceride |
| 日期: | 2014-11 |
| 上傳時間: | 2015-05-06 21:26:41 (UTC+8) |
| 出版者: | Informa Healthcare |
| 摘要: | C57BL/6J mice were divided into control group (C), CLA, c9t11, or t10c12 groups. CLA and t10c12 significantly increased alpha-tocopherol levels in the plasma and various tissues in experiment 1. The CLA and t10c12 groups also showed a significant increase in hepatic alpha-tocopherol transfer protein (alpha-TTP) levels. In experiment 2, mice were divided into control, CLA, R (rosiglitazone, a PPAR gamma agonist), or CLA+ R groups. Vitamin E levels in the liver, epididymal fat pad, kidney, and plasma were increased by CLA, and this effect was reduced in the CLA+ R group. t10, c12-CLA is the most active isomer in the CLA mixture in the regulation of tissue vitamin E status and alpha-TTP protein levels in mice. The increase in liver vitamin E status in CLA-fed mice is mainly due to the effect of PPAR gamma inhibition. |
| 關聯: | International Journal of Food Sciences and Nutrition, v.65 n.7, pp.841-847 |
| 显示于类别: | [保健營養系(所) ] 期刊論文
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