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https://ir.cnu.edu.tw/handle/310902800/28710
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| 標題: | The Impact of Inadequate Terminal Disinfection on an Outbreak of Imipenem-Resistant Acinetobacter baumannii in an Intensive Care Unit |
| 作者: | Liu, Wei-Lun
Liang, Hsueh-Wen
Lee, Mei-Feng
Lin, Hsin-Lan
Lin, Yu-Hsiu
Chen, Chi-Chung
Chang, Ping-Chin
Lai, Chih-Cheng
Chuang, Yin-Ching
Tang, Hung-Jen |
| 貢獻者: | 保健營養系 |
| 關鍵字: | FIELD GEL-ELECTROPHORESIS
CRITICALLY-ILL PATIENTS
RISK-FACTORS
NOSOCOMIAL BACTEREMIA
MULTIDRUG
INFECTION
MORTALITY
CRITERIA
COHORT |
| 日期: | 2014-09 |
| 上傳時間: | 2015-05-06 21:26:01 (UTC+8) |
| 出版者: | Public Library Science |
| 摘要: | Background: This study was conducted to investigate an outbreak caused by imipenem-resistant Acinetobacter baumannii (IRAB) in a medical intensive care unit (ICU) in a regional hospital. Methods: In response to an IRAB outbreak from October 2012 to February 2013, we developed several infection control measures, including an extensive review process of environmental cleaning and disinfection, and used molecular methods to identify each clinical and environmental IRAB isolate. Results: During this five-month period, 22 patients were colonized with IRAB and 18 patients had IRAB infections. The in-hospital mortality rate was significantly higher among patients with infections rather than colonizations (44.4% vs 9.1%, p = 0.028). Additionally, nine environmental specimens, including five specimens collected after terminal disinfection, were positive for IRAB. 12 environmental isolates and 28 of 36 available clinical isolates belonged to one unique pulsotype A, which was confirmed by molecular methods. We found the concentration of disinfectant, 0.08% sodium hypochlorite, was inadequate. After correcting the environmental cleansing methods, the surveillance study showed no further IRAB isolates on the control panel surfaces of the medical equipment or in patients in the ICU. Additionally, an in vitro study of IRAB immersed in different concentrations of sodium hypochlorite showed that 0.5% sodium hypochlorite eradicates IRAB after 30 seconds of inoculation, but 0.08% sodium hypochlorite only reduces the bacterial load. Conclusions: This study highlights the importance of the preparation of disinfectants to adequately achieve environmental disinfection in the control of IRAB outbreaks in the ICU. |
| 關聯: | Plos One, v.9 n.9, e107975 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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