The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting

doi:10.1016/j.ejphar.2013.10.008

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/28705

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28705

Title:	The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting
Authors:	Chu, Chin-Chen Hsing, Chung-Hsi Shieh, Ja-Ping Chien, Chih-Chiang Ho, Chiu-Ming Wang, Jhi-Joung
Contributors:	休閒保健管理系
Keywords:	Glucocorticoids Dexamethasone Emesis CINV RINV PONV
Date:	2014-01
Issue Date:	2015-05-06 21:25:51 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also effective, alone or combined with other antiemetics, for preventing nausea and vomiting. Dexamethasone, one of the glucocorticoids, has been suggested as a first-line drug for preventing low-level emetogenic chemotherapy- and radiotherapy-induced nausea and vomiting, and in patients with only one or two risks for postoperative nausea and vomiting (PONV). Dexamethasone combined with 5-HT3 or tachykinin NK1 antagonists is also suggested for higher-level emetogenic chemotherapy and radiotherapy and for patients at high risk for PONV. Glucocorticoids may act via the following mechanisms: (1) anti-inflammatory effect; (2) direct central action at the solitary tract nucleus, (3) interaction with the neurotransmitter serotonin, and receptor proteins tachykinin NK1 and NK2, alpha-adrenaline, etc.; (4) maintaining the normal physiological functions of organs and systems; (5) regulation of the hypothalamic-pituitary-adrenal axis; and (6) reducing pain and the concomitant use of opioids, which in turn reduces opioid-related nausea and vomiting. (C) 2013 Published by Elsevier B.V.
Relation:	European Journal of Pharmacology, v.722, pp.48-54
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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