T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells

doi:10.1016/j.clim.2014.02.006

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Title:	T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells
Authors:	Lin, Ming-Hong Yeh, Li-Tzu Chen, Shyi-Jou Chiou, Hsin-Ying C. Chu, Chin-Chen Yen, Linju B. Lin, Kuo-I Chang, Deh-Ming Sytwu, Huey-Kang
Contributors:	休閒保健管理系
Keywords:	BLIMP-1 EAE Th1 Th17 Treg IL-10
Date:	2014-04
Issue Date:	2015-05-06 21:25:47 (UTC+8)
Publisher:	Academic Press Inc Elsevier Science
Abstract:	Recently, we demonstrated that B lymphocyte-induced maturation protein 1 (BLIMP-1) has a role in regulating the differentiation and effector function of Th1 and Th17 tells. As these cells play critical roles in the induction and pathogenesis of experimental autoimmune encephalomyelitis (EAE), we investigated the potential role of T cell BLIMP-1 in modulating MOG(35-55)-induced EAE. We established T cell-specific BLIMP-1 conditional knockout (CKO) NOD mice to dissect the role of BLIMP-1 in EAE using loss-of-function model. Our results indicate that EAE severity is dramatically exacerbated in CKO mice. The numbers of CNS-infiltrating Th1, Th17, IFN-gamma+IL-17A(+), and IL-21(+)IL-17A(+) CD4(+) T cells are remarkably increased in brain and spinal cord of CKO mice. Moreover, the ratio of Tregs/effectors and IL-10 production of Tregs are significantly downregulated in CNS of CKO mice. We conclude that BLIMP-1 suppresses autoimmune encephalomyelitis via downregulating Th1 and Th17 cells and impairing Treg cells. (C) 2014 Elsevier Inc. All rights reserved.
Relation:	Clinical Immunology, v.151 n.2, pp.101-113
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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