Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model

doi:10.3892/or.2014.3544

CNU IR > College of Smart Living > Dept. of Senior Service and Health Management > Periodical Articles > Item 310902800/28700

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题名:	Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model
作者:	Shan, Yan-Shen Hsu, Hui-Ping Lai, Ming-Derg Yen, Meng-Chi Fang, Jung-Hua Weng, Tzu-Yang Chen, Yi-Ling
贡献者:	老人服務事業管理系
关键词:	colon cancer interleukin-6 mucin 2 small interfering RNA therapeutic effects
日期:	2014-12
上传时间:	2015-05-06 21:25:41 (UTC+8)
出版者:	Spandidos Publ Ltd
摘要:	Mucin 2 (MUC2) is the major secreted mucin of the large intestine and is expressed by adenomas and mucinous carcinomas. Since colon cancer is associated with a proinflammatory microenvironment and dysregulated MUC2 expression, the aim of this study was to characterize the effects of MUC2 gene expression in colon tumor progression using colonic cancer cells. CT26 colon cancer cells were stably transfected with MUC2 siRNA (MUC2 RNAi) or a control construct containing a nonspecific sequence (scrambled RNAi). Expression of MUC2 was significantly decreased in the MUC2 RNAi cell clones. Although MUC2 suppression did not affect the cell growth of colon cancer cells in vitro, MUC2 knockdown promoted tumor growth in an orthotopic colon cancer model in vivo. MUC2 silencing also increased interleukin (IL)-6 secretion by colon cancer cells. IL-6 neutralization attenuated tumor formation by MUC2 RNAi cells; it also increased CD8 T cell infiltration into the peritoneum. Taken together, to the best of our knowledge, this is the first study indicating that the immune response to cancer cells plays an important role in tumor growth regulated by MUC2. Furthermore, given the effects of MUC2 on IL-6 secretion, its targeting may represent a potentially useful strategy to treat colonic carcinomas.
關聯:	Oncology Reports, v.32 n.6, pp.2335-2342
显示于类别:	[Dept. of Senior Service and Health Management] Periodical Articles

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