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| 標題: | Serum vascular adhesion protein-1 predicts all-cause mortality and cancer-related mortality in subjects with colorectal cancer |
| 作者: | Li, Yu-I
Hung, Ji-Shiang
Yu, Tse-Ya
Liou, Jyh-Ming
Wei, Jung-Nan
Kao, Hsien-Li
Chuang, Lee-Ming
Shun, Chia-Tung
Lee, Po-Huang
Lai, Hong-Shiee
Su, Chien-Yin
Li, Hung-Yuan
Liang, Jin-Tung |
| 貢獻者: | 職業安全衛生系 |
| 關鍵字: | Vascular adhesion protein-1
Semicarbazide-sensitive amine oxidase
Primary amine oxidase
Mortality
Colorectal cancer |
| 日期: | 2014-01 |
| 上傳時間: | 2015-05-06 21:25:25 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | Background: Vascular adhesion protein-1 (VAP-1) participates in inflammation and catalyzes the breakdown of amines to produce aldehyde, hydrogen peroxide, and ammonia. Serum VAP-1 can predict cancer mortality, including colorectal cancer (CRC) mortality, in type 2 diabetic subjects. However, it remains unknown if serum VAP-1 can predict mortality in CRC patients. This prospective cohort study investigates if serum VAP-1 is a novel biomarker for mortality prediction in CRC. Methods: We enrolled 300 CRC patients. Preoperative serum VAP-1 was measured by time-resolved immunofluorometric assay. They were followed until September 2009 or death, which was ascertained by the National Death Registration System. Results: The median follow-up period was 4.7 years. Compared with normal counterpart, VAP-1 immunoactivity was upregulated in CRC tissues, especially at the invasion front. Serum VAP-1 can independently predict all-cause mortality (HR: 1.0026, 95% Cl: 1.0003-1.0050, P < 0.05) and cancer-related mortality (HR: 1.0026, 95% Cl: 1.0001-1.0050, P <0.05). A risk score composed of age, gender, carcinoembryonic antigen (CEA) >5 ng/ml, tumor grading, tumor staging, and serum VAP-1 could stratify CRC patients into low-, intermediate-, and high-risk subgroups, with a 5-year mortality rate of 10%, 34%, and 78%, respectively. Conclusions: Serum VAP-1 predicts mortality independently and improves risk stratification in CRC subjects. (C) 2013 Elsevier B.V. All rights reserved. |
| 關聯: | Clinica Chimica Acta, v.428 n., pp.51-56 |
| 顯示於類別: | [職業安全衛生系(含防災所)] 期刊論文
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