Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28681
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    標題: Risk of Head and Neck Cancer in Patients With Diabetes Mellitus A Retrospective Cohort Study in Taiwan
    作者: Tseng, Kuo-Shu
    Lin, Charlene
    Lin, Yung-Song
    Weng, Shih-Feng
    貢獻者: 醫務管理系
    關鍵字: SQUAMOUS-CELL CARCINOMA
    POPULATION-BASED COHORT
    ORAL-CANCER
    ABERRANT METHYLATION
    METABOLIC SYNDROME
    CONSENSUS REPORT
    BREAST-CANCER
    GTPASE GENE
    INSULIN
    GROWTH
    日期: 2014-08
    上傳時間: 2015-05-06 21:24:59 (UTC+8)
    出版者: Amer Medical Assoc
    摘要: IMPORTANCE An increasing body of evidence suggests that certain types of cancers are more common in people with diabetes mellitus (DM). However, the risk of head and neck cancer (HNC) in patients with DM has seldom been explored. OBJECTIVE To examine the risk of HNC in patients with DM. DESIGN, SETTING, AND PARTICIPANTS In this retrospective cohort study using Taiwan's Longitudinal Health Insurance Research Database, we compared 89 089 patients newly diagnosed as having DM and controls without DM-related medical claims matched for comorbidities (obesity, coronary artery disease, hyperlipidemia, and hypertension), sex, and age. Patients were assessed from the index date until the end of follow-up on December 31, 2011, or until the patient was censored because of death. MAIN OUTCOMES AND MEASURES The incidence of HNC at the end of 2011. RESULTS The incidence of HNC was 1.47 times higher in patients newly diagnosed as having DM than was the risk of a first malignant tumor in the control group (adjusted hazard ratio [AHR], 1.48; 95% CI, 1.31-1.67). The risks of oral cancer (AHR, 1.74; 95% CI, 1.47-2.06), oropharyngeal cancer (AHR, 1.53; 95% CI, 1.01-2.31), and nasopharyngeal carcinoma (AHR, 1.40; 95% CI, 1.03-1.89) were significantly higher in patients with DM than in controls. CONCLUSIONS AND RELEVANCE Diabetes is associated with an increased risk of developing HNC. The risks of developing oral cavity cancer, oropharyngeal cancer, and nasopharyngeal carcinoma were significantly higher in patients with DM.
    關聯: Jama Otolaryngology-Head & Neck Surgery, v.140 n.8, pp.746-753
    顯示於類別:[醫務管理系(所)] 期刊論文

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