Rimantadine and 2-adamantanamine elicit local anesthesia to cutaneous nociceptive stimuli in a rat model

doi:10.1111/fcp.12012

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/28679

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標題:	Rimantadine and 2-adamantanamine elicit local anesthesia to cutaneous nociceptive stimuli in a rat model
作者:	Hung, Ching-Hsia Chu, Chin-Chen Chen, Yu-Chung Chen, Yu-Wen Wang, Jhi-Joung
貢獻者:	休閒保健管理系
關鍵字:	infiltrative cutaneous anesthesia 2-adamantanamine rimantadine lidocaine
日期:	2014-04
上傳時間:	2015-05-06 21:24:55 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	The aim of this study was to investigate infiltrative cutaneous anesthesia of 2-adamantanamine and rimantadine. After subcutaneous injections of drugs in rats, the blockade of cutaneous trunci muscle reflex by 2-adamantanamine and rimantadine was evaluated. Lidocaine, a common local anesthetic, was used as control. We showed that rimantadine and 2-adamantanamine as well as the local anesthetic lidocaine produced infiltrative anesthesia of skin in a dose-dependent fashion. Saline (vehicle) group displayed no cutaneous anesthesia. The relative potency of these drugs was rimantadine [23.8 (21.1-26.8)]=lidocaine [26.4 (22.7-30.6)]>2-adamantanamine [64.6 (55.0-75.9)] (P<0.01). On an equianesthetic basis [25% effective dose (ED25), ED50, and ED75], rimantadine and 2-adamantanamine had longer duration of action than lidocaine (P<0.05). Neither local injection of saline nor intraperitoneal administration of a large dose of drugs elicited cutaneous anesthesia (data not shown). These data demonstrated for the first time that rimantadine had a similar potent and longer duration of skin infiltrative anesthesia than did lidocaine, whereas 2-adamantanamine had a less potency but longer duration of cutaneous anesthesia than did lidocaine.
關聯:	Fundamental & Clinical Pharmacology, v.28 n.2, pp.199-204
显示于类别:	[休閒保健管理系(所)] 期刊論文

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